研究成果

2020.12.25	武川睦寛（東京大学医科学研究所・分子シグナル制御分野） Matsushita M, Nakamura T, Moriizumi H, Miki H, and Takekawa M. Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress. *Science Advances* 6, eaay9778, 2020
	武川睦寛（東京大学医科学研究所・分子シグナル制御分野） Weng JS, Nakamura T, Moriizumi H, Takano H, Yao R, and Takekawa M. MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing. *Commun Biol*2, 227, doi.org/10.1038/s42003-019-0478-3, 2019
	武川睦寛（東京大学医科学研究所・分子シグナル制御分野） Nakamura R, Numata T, Kasuya G, Yokoyama T, Nishizawa T, Kusakizako T, Kato T, Hagino T, Dohmae N, Inoue M, Watanabe K, Ichijo H, Kikkawa M, Shirouzu M, Jentsch TJ, Ishitani R, Okada Y, Nureki O. Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation. *Commun Biol*. 3, 240. doi: 10.1038/s42003-020-0951-z, 2020
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Kawaguchi M, Okabe T, Okudaira S, Hama K, Kano K, Nishimasu H, Nakagawa H, Ishitani R, Kojima H, Nureki O, Aoki J, Nagano T. Identification of Potent In Vivo Autotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain. *J Med Chem*. 63, 3188-3204. doi: 10.1021/acs.jmedchem.9b01967. 2020
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Yamaguchi S, Oe A, Nishida KM, Yamashita K, Kajiya A, Hirano S, Matsumoto N, Dohmae N, Ishitani R, Saito K, Siomi H, Nishimasu H, Siomi MC, Nureki O. Crystal structure of Drosophila Piwi. *Nat Commun*. 11, 858. doi: 10.1038/s41467-020-14687-1, 2020
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Kusakizako T, Miyauchi H, Ishitani R, Nureki O. Structural biology of the multidrug and toxic compound extrusion superfamily transporters. *Biochim Biophys Acta Biomembr*. 183154. doi: 10.1016/j.bbamem.2019.183154. 2019
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Lee Y, Wiriyasermkul P, Jin C, Quan L, Ohgaki R, Okuda S, Kusakizako T, Nishizawa T, Oda K, Ishitani R, Yokoyama T, Nakane T, Shirouzu M, Endou H, Nagamori S, Kanai Y, Nureki O. Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc. *Nat Struct Mol Biol*. 26, 510-517, 2019
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Hirano S, Abudayyeh OO, Gootenberg JS, Horii T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O. Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9. *Nat Commun*. 10, 1968. doi: 10.1038/s41467-019-09741-6, 2019
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Kato T, Kumazaki K, Wada M, Taniguchi R, Nakane T, Yamashita K, Hirata K, Ishitani R, Ito K, Nishizawa T, Nureki O. Crystal structure of plant vacuolar iron transporter VIT1. *Nat Plants*. 5, 308-315, 2019
	上野　匡（東京大学大学院薬学系研究科・薬品代謝化学教室） Takasugi T, Hanaoka K, Sasaki A, Ikeno T, Komatsu T, Ueno T, Yamada K, Urano, Y. Development of a platform for activatable fluorescent substrates of glucose transporters (GLUTs). *Bioorganic & Medicinal Chemistry*,27,2122-2126,2019.
	上野　匡（東京大学大学院薬学系研究科・薬品代謝化学教室） Ogasawara A, Kamiya M, Sakamoto K, Kuriki Y, Fujita K, Komatsu T, Ueno T, Hanaoka K, Onoyama H, Abe H, Tsuji Y, Fujishiro M, Koike K, Fukayama M, Seto Y, Urano Y. Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer. *Bioconjugate Chemistry* 30, 4, 2019.
	武川睦寛（東京大学医科学研究所・分子シグナル制御分野）久保田裕二、藤岡興、武川睦寛　 O-GlcNAｃ化蛋白質の検出と定量的解析を可能にするレクチン親和性ゲル電気泳動法の開発と応用. 生物物理化学-電気泳動- 63,41-45.2019
	井上純一郎（東京大学医科学研究所・分子発癌分野） Yamamoto, M., Du, Q., Song, J., Wang, H., Watanabe, A., Tanaka, Y., Kawaguchi, Y., Inoue, J.* and Matsuda, Z.* Cell-cell and virus-cell fusion assay-based analyses of alanine insertion mutants in the distal a9 portion of the JRFL gp41 subunit from HIV-1. *J. Biol. Chem.* 294(14), 5677-5687 (2019). doi: 10.1074/jbc.RA118.004579.
	井上純一郎（東京大学医科学研究所・分子発癌分野） Radwan, M.O., Koga, R., Hida, T., Ejima, T., Kanemaru, Y., Tateishi, H., Okamoto, Y., Inoue, J., Fujita, M. and Otsuka, M.* Minimum structural requirements for inhibitors of the zinc finger protein TRAF6. *Bioorg*. Med. Chem. Lett. 29, 2162-2167 (2019). https://doi.org/10.1016/j.bmcl.2019.06.050
	井上純一郎（東京大学医科学研究所・分子発癌分野） Yamamoto, M., Abe, C., Wakinaga, S., Sakane, K., Yumiketa, Y., Taguchi, Y., Matsumura, T., Ishikawa, K., Fujimoto, J., Semba, K., Miyauchi, M., Akiyama, T. and Inoue, J.* TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion. *Commun. Biol.* 2, Article number: 292 (2019). doi.org/10.1038/s42003-019-0547-7
	井上純一郎（東京大学医科学研究所・分子発癌分野） Horie, K., Kato, T., Kudo, T., Sasanuma, H., Miyauchi, M., Akiyama, N., Miyao, T., Seki, T., Ishikawa, T., Takakura, Y., Shirakawa, M., Shiba, D., Hamada, M., Jeon, H., Yoshida, N., Inoue, J., Muratani, M., Takahashi, S., Ohno, H. and Akiyama, T. Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight. Sci. Rep. 9:19866 (2019). doi: 10.1038/s41598-019-56432-9.
	井上純一郎（東京大学医科学研究所・分子発癌分野） Kandeel, M., Yamamoto, M., Al-Taher, A., Watanabe, A., Oh-hashi, K., Park, B.-K., Kwon, H.-J., Inoue, J. and Al-Nazawi, M. Discovery of new small molecule inhibitors of Middle East Respiratory Syndrome Coronavirus fusion by targeting cavities on heptad repeat trimers. *Biomol. Ther.* (2020) doi: 10.4062/biomolther.2019.202
	井上純一郎（東京大学医科学研究所・分子発癌分野） Nakamura, T., Hashikawa, C., Okabe, K., Yokote, Y., Chirifu, M., Toma-Fukai, S., Nakamura, N., Matsuo, M., Kamikariya, M., Okamoto, Y., Gohda, J., Akiyama, T., Semba, K., Ikemizu1, S., Otsuka, M., Inoue, J. and Yamagata, Y. Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity. *Sci. Rep.* 10:5152 (2020). doi: 10.1038/s41598-020-61972-6.
	井上純一郎（東京大学医科学研究所・分子発癌分野） Kozuka-Hata, H., Kitamura, A., Hiroki, T., Aizawa, A., Tsumoto, K., Inoue, J. and Oyama, M. System-wide analysis of protein acetylation and ubiquitination reveals diversified regulation in human cancer cells. *Biomolecules* 10:411 (2020). doi: 10.3390/biom10030411.
	井上純一郎（東京大学医科学研究所・分子発癌分野） Niederkorn, M., Hueneman, K, Choi, K, Varney, M.E., Romano, L., Pujato, M.A., Greis, K.D., Inoue, J., Meetei, R. and Starczynowski. D.T. TIFAB regulates USP15-mediated p53 signaling during stressed and malignant hematopoiesis. *Cell Rep.* 30, 2776-2790.e6. doi:10.1016/j.celrep.2020.01.093
	井上純一郎（東京大学医科学研究所・分子発癌分野） Yoshino, S., Matsui, Y., Fukui, Y., Seki, M., Yamaguchi, K., Kanamori, A., Saitoh, Y., Shimamura, T., Suzuki, Y., Furukawa, Y., Kaneko, S., Seiki, M., Murakami, Y., Inoue, J. and Sakamoto, T. EXOSC9 depletion attenuates P-body formation, stress resistance, and tumorigenicity of cancer cells. *Sci. Rep.* 10:9275 (2020). doi: 10.1038/s41598-020-66455-2.
	井上純一郎（東京大学医科学研究所・分子発癌分野） Yamamoto, M., Kiso, M., Sakai-Tagawa, Y., Iwatsuki-Horimoto, K., Imai, M., Takeda, M., Kinoshita, N., Ohmagari, N., Gohda, J., Semba, K., Matsuda, Z., Kawaguchi, Y., Kawaoka Y. and Inoue J. The anticoagulant nafamostat potently inhibits SARS-CoV-2 S protein-mediated fusion in a cell fusion assay system and viral infection in vitro in a cell-type-dependent manner. *Viruses* 12, 629 (2020); doi:10.3390/v12060629.
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Oikawa D, Hatanaka N, Suzuki T, and Tokunaga F. Cellular and mathematical analysis of LUBAC involvement in T cell receptor-mediated NF-κB activation pathway. *Frontiers in Immunology* doi: 10.3389/fimmu.2020.601926, in press
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Tokunaga F, Tsukagoshi H, and Ishikawa O. The synchronized gene expression of retrotransposons and type I interferon in dermatomyositis. Journal of American Academy of Dermatologydoi: 10.1016/j.jaad.2020.05.051, in press [PubMed]
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Takahashi H, Yamanaka S, Kuwada S, Higaki K, Kido K, Sato Y, Fukai S, Tokunaga F, and Sawasaki T. A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors. Biomedicines 8, 152, doi: 10.3390/biomedicines8060152, 2020 [PubMed]
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Oikawa D, Sato Y, Ito H, and Tokunaga F Linear ubiquitin code: Its writer, erasers, decoders, inhibitors, and implications in disorders. *International Journal of Molecular Science*21, 3381, doi: 10.3390/ijms21093381, 2020 [PubMed]
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F. Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses. *Communications Biology* 3, 16, doi: 10.1038/s42003-020-0882-8, 2020 [PubMed]
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Nakayama Y, Tsuji K, Ayaki T, Mori M, Tokunaga F, Ito H. Linear Polyubiquitin Chain Modification of TDP-43-Positive Neuronal Cytoplasmic Inclusions in Amyotrophic Lateral Sclerosis. Journal of Neuropathology and Experimental Neurology79, 256-265, doi: 10.1093/jnen/nlz135, 2020 [PubMed]
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Yamanaka S, Sato Y, Oikawa D, Goto E, Fukai S, Tokunaga F, Takahashi H, and Sawasaki T. Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling. *Biochemical and Biophysical Research Communications* 524, 1-7, doi: 10.1016/j.bbrc.2019.12.049, 2020 [PubMed]
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Uematsu A, Kido K, Takahashi H, Takahashi C, Yanagihara Y, Saeki N, Yoshida S, Maekawa M, Honda M, Kai T, Shimizu K, Higashiyama S, Imai Y, Tokunaga F, and Sawasaki T. The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD. *Journal of Biological Chemistry* 294, 14135-14138, doi: 10.1074/jbc.RA119.010119, 2019 [PubMed]
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Nakayama Y, Sakamoto S, Tsuji K, Ayaki T, Tokunaga F, and Ito H. Identification of linear ubiquitin chain immunoreactivity in tau pathology of Alzheimer’s disease. *Neuroscience Letters*703, 53-57, doi: 10.1016/j.neulet.2019.03.017, 2019 [PubMed]
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学）及川大輔、伊藤秀文、徳永文稔直鎖状ユビキチン鎖の神経変性疾患への関与とLUBAC阻害剤の開発. (公社)日本生化学会生化学 92, 28-34, doi:10.14952/SEIKAGAKU.2020.920028, 2020
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学）高橋宏隆、山中聡士、徳永文稔、澤崎達也ヒト脱ユビキチン化酵素タンパク質アレイの開発とその応用例. (公社)日本生化学会生化学 92. 64-74, doi: 10.14952/SEIKAGAKU.2020.920064, 2020
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学）徳永文稔創薬を見据えた直鎖状ユビキチン鎖生成酵素(LUBAC)阻害剤開発. (公社)日本薬学会ファルマシア 56, 26-30, doi: 10.14894/faruawpsj.56.1_26, 2020
	鈴木　貴（大阪大学数理・データ科学教育研究センター） Ito T, Kumagai Y, Itano K, Maruyama T, Tamura K, Kawasaki S, Murakami Y, and Suzuki T. Mathematical analysis of geﬁtinib resistence of lung adenocarcinoma caused by MET ampliﬁcation. Biochemical and Biophysical Research Communications (Ito), 511(3): 544-550, 2019, doi:10.1016/j.bbrc.2019.02.086 [PubMed]
	鈴木　貴（大阪大学数理・データ科学教育研究センター） Hatanaka N, Seki T, Inoue J, Tero A, and Suzuki T. Critical roles of IκBα and RelA phosphorylation in transitional oscillation in NF−κB signaling module. J. Theor. Biol. 462 (2019) 479-489, doi:10.1016/j.jtbi.2018.11.023.Epub2019Nov27 [PubMed]
	鈴木　貴（大阪大学数理・データ科学教育研究センター） Kobayashi M, Yamada Y, and Suzuki T. Lotka-Volterra systems with periodic orbits. F.E. 62 (2019) 129-155, doi:10.1619/fesi.62.129
	鈴木　貴（大阪大学数理・データ科学教育研究センター） M Pierre, Yamada Y, and Suzuki T. Dissipative reaction diﬀusion systems with quadratic growth. Indiana Univ. Math. J. 68 (2019) 291-322，doi:10.1512/iumj.2019.68.7447
	鈴木　貴（大阪大学数理・データ科学教育研究センター） K Fellner, E Latos, and Suzuki T. Large-time asymptotics of a pulic goods game model with diﬀusion. Monatshefte fur Matematik 190 (2019) 101-121, doi:10.1007/s00605-019-01275-9
	鈴木　貴（大阪大学数理・データ科学教育研究センター） Fujie K, and Suzuki T. Global existence and boundedness in a fully parabolic 2D attractionrepulsion system: chometaxis-dominant case. Adv. Math. Sci. Appl. 28 (2019)
	鈴木　貴（大阪大学数理・データ科学教育研究センター） Toyota Y, and Suzuki T. 2D Trudinger-Moser inequality for Boltzmann-Poisson equation with continuously distributed muti-intensities. to appear in; Cal. Var. 58 (2019) 77, doi:10.1007/s00536-019-1520-5 arxiv.org/abs/1803.01103
	鈴木　貴（大阪大学数理・データ科学教育研究センター） N.A.N Azuan, N Yaacob, C Poignard, S Shafie, M.A.B Admon, and Suzuki T. Two-dimensional signal transduction during the formation of invadopodia. Malaysian J. Math. Sci. 13 (2019) 1550164
	鈴木　貴（大阪大学数理・データ科学教育研究センター） Y Yang, X Cheng, and Suzuki T. Darboux tranformations and exact solutions for the integrable nonlocal Lakshmanan-Porsezian-Daniel equation. Applied Mathematics Letters. B 99, January 2020, 105998, doi:10.1016/j.aml.2019.105998
	鈴木　貴（大阪大学数理・データ科学教育研究センター） Suzuki T. Dissipative reaction diﬀusion systems with polynomial growth. Adv. Diﬀerential Equations 25 (2020) 81-104
	鈴木　貴（大阪大学数理・データ科学教育研究センター） Oikawa D,Hatanaka N,Tokunaga F,and Suzuki T. Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-mediated NF-κB Activation Pathway. Frontiers Immulnology,in press doi: 10.3389/fimmu.2020.601926
	久保田浩行（九州大学生体防御医学研究所・統合オミクス分野） Kawata K., Yugi K., Hatano A., Kokaji T., Tomizawa Y., Fujii M., Uda S., Kubota H., Matsumoto M., Nakayama K. I. and Kuroda S. Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data. *Genes Cells*., 24: 82-93, 2019
	久保田浩行（九州大学生体防御医学研究所・統合オミクス分野） Fujii, M., Murakami Y., Karasawa Y., Sumitomo Y., Fujita S., Koyama M., Uda, S., Kubota H., Inoue H., Konishi K., Oba S., Ishii S. and Kuroda. Logical design of oral glucose ingestion pattern minimizing blood glucose in human. *NPJ Syst. Biol. Appl.*, 2019
	久保田浩行（九州大学生体防御医学研究所・統合オミクス分野） Ohigashi I.,Tanaka Y., Kondo K., Fujimori S., Kondo H., Palin AC., Hoffmann V., Kozai M., Matsushita Y., Uda, S., Motosugi, R., Hamazaki J., Kubota, H., Murata S., Tanaka K., Katagiri T., Kosako H. and Takahama Y. *Cell Rep.*, Vol. 29(9), 2901-2916, 2019
	久保田浩行（九州大学生体防御医学研究所・統合オミクス分野）久保田浩行　トランスオミックス解析の現状. 医薬品開発におけるオミクス解析技術,147-154.2020
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Furihata H#, Yamanaka S#, Honda T, Miyauchi Y, Asano A, Shibata N, Tanokura M, Sawasaki T, Miyakawa T. Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide. Nat Commun.* 2020, 11(1): 4578. (#co-first author, *corresponding author) [PubMed]
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Yamanaka S, Shoya Y. Matsuoka S, Nishida-Fukuda H, Shibata N, Sawasaki T. An IMiD-induced SALL4 degron system for selective degradation of target proteins. *Commun Biol.* 2020, 3: 515. [PubMed]
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Inoue SI, Kaiserli E, Zhao X, Waksman T, Takemiya A, Okumura M, Takahashi H, Seki M, Shinozaki K, Endo Y, Sawasaki T, Kinoshita T, Zhang X, Christie JM, Shimazaki KI. CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana. *Plant J*. 2020, 104(3): 679–692. [PubMed]
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Kaneko N, Kurata M, Yamamoto T, Shigemura T, Agematsu K, Yamazaki T, Takeda H, Sawasaki T, Koga T, Kawakami A, Yachie A, Migita K, Yoshiura KI, Urano T, Masumoto J. KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1β from PBMCs in a patient with Muckle-Wells syndrome. *Sci Rep.* 2020 10(1): 13562. [PubMed]
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Takahashi H, Yamanaka S, Kuwada S, Higaki K, Kido K, Sato Y, Fukai S, Tokunaga F, and Sawasaki T. A human DUB protein array for clarification of linkage specificity of polyubiquitin chain and application to evaluation of its inhibitors. *Biomedicines* 2020, 8(6): 152. [PubMed]
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Kido K, Yamanaka S, Nakano S, Motani K, Shinohara S, Nozawa A, Kosako H, Ito S, Sawasaki T. AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions. *eLife*. 2020 9: e54983 [PubMed]
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Uemura T, Hachisu M, Desaki Y, Ito A, Hoshino R, Sano Y, Nozawa A, Mujiono K, Galis I, Yoshida A, Nemoto K, Miura S, Nishiyama M, Nishiyama C, Horito S, Sawasaki T, Arimura GI. Soy and Arabidopsis receptor-like kinases respond to polysaccharide signals from Spodoptera species and mediate herbivore resistance. *Commun Biol.* 2020, 3(1): 224. [PubMed]
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Miyoshi S, Tokunaga S, Ozawa T, Takeda H, Aono M, Miyoshi T, Kishi H, Muraguchi A, Shimizu SI, Nozawa A, Sawasaki T. Production of a rabbit monoclonal antibody for highly sensitive detection of citrus mosaic virus and related viruses. *PLoS One.* 2020, 15(4): e0229196. [PubMed]
	澤崎達也（愛媛大学　プロテオサイエンスセンター）高橋宏隆, 山中聡士, 徳永文稔, 澤崎達也：「ヒト脱ユビキチン化酵素タンパク質アレイの開発とその応用例」生化学第92巻1号: 64-74 (2020).
	澤崎達也（愛媛大学　プロテオサイエンスセンター）高橋宏隆, 山中聡士：「コムギ無細胞合成系による脱ユビキチン化酵素アレイの作製とDUB阻害剤開発への応用」ファルマシア第56巻1号: 51-55 (2020).
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Yamanaka Y, Sato Y, Oikawa D, Goto E, Fukai S, Tokunaga F, Takahashi H, Sawasaki T. Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling. *Biochem Biophys Res Commun.*2020, 524(1): 1-7. [PubMed]
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Hayashi M, Sugimoto H, Takahashi H, Seki M, Shinozaki K, Sawasaki T, Kinoshita T, Inoue S.Raf-like kinases CBC1 and CBC2 negatively regulate stomatal opening by negatively regulating plasma membrane H+-ATPase phosphorylation in Arabidopsis. *Photochem Photobiol Sci*. 2020, 19(1): 88-98. [PubMed]
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Morishita R, Sugiyama S, Denda M, Tokunaga S, Kido K, Shioya R, Ozawa S, Sawasaki T. CF-PA2Vtech: a cell-free human protein array technology for antibody validation against human proteins. *Sci Rep*. 2019, 9(1): 19349. [PubMed]
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Nomura S, Takahashi H, Suzuki J, Kuwahara M, Yamashita M, Sawasaki T. Pyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro. *Sci Rep*. 2019, 9(1): 17335. [PubMed]
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Uematsu A, Kido K, Takahashi H, Takahashi C, Yanagihara Y, Saeki N, Yoshida S, Maekawa M, Honda M, Kai T, Shimizu K, Higashiyama S, Imai Y, Tokunaga F, Sawasaki T. MIB2 E3 ubiquitin ligase enhances inflammation through degradation of the deubiquitinating enzyme CYLD. *J Biol Chem*. 2019, 294(38): 14135–14148. [PubMed]
澤崎達也（愛媛大学　プロテオサイエンスセンター） Maekawa M, Hiyoshi H, Nakayama J, Kido K, Sawasaki T, Semba K, Kubota E, Joh T, Higashiyama S. Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells. *Biochem Biophys Res Commun*. 2019 516(4): 1116-1122. [PubMed]
澤崎達也（愛媛大学　プロテオサイエンスセンター） Miyamoto T, Uemura T, Nemoto K, Daito M, Nozawa A, Sawasaki T, Arimura GI. Tyrosine Kinase-Dependent Defense Responses Against Herbivory in Arabidopsis. *Front Plant Sci*. 2019 10: 776. [PubMed]
澤崎達也（愛媛大学　プロテオサイエンスセンター） Miyakawa K, Matsunaga S, Yokoyama M, Nomaguchi M, Kimura Y, Nishi M, Kimura H, Sato H, Hirano H, Tamura T, Akari H, Miura T, Adachi A, Sawasaki T, Yamamoto N, Ryo A. PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation. *Nat Commun.* 2019, 10(1): 1844. [PubMed]
澤崎達也（愛媛大学　プロテオサイエンスセンター） Ali MRM, Uemura T, Ramadan A, Adachi K, Nemoto K, Nozawa A, Hoshino R, Abe H, Sawasaki T, Arimura GI. The Ring-type E3 Ubiquitin Ligase JUL1 Targets the VQ-motif Protein JAV1 to Coordinate Jasmonate Signaling. Plant Physiol. 2019, 179(4): 1273-1284. [PubMed]
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） Watanabe M, Arii J, Takeshima K, Fukui A, Shimojima M, Kozuka-Hata H, Oyama M, Minamitani T, Yasui T, Kubota Y, Takekawa M, Kosugi I, Maruzuru Y, Koyanagi N, Kato A, Mori Y, and Kawaguchi Y. Prohibitin-1 Contributes to the Cell-to-Cell Transmission of Herpes Simplex Virus 1. *J. Virol.*, doi:10.1128/JVI.01413-20, Epub ahead of print, 2020. [PubMed]
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） Tsuboi Y, Oyama M, Kozuka-Hata H, Ito A, Matsubara D, and Murakami Y. CADM1 suppresses c-Src activation by binding with Cbp on membrane lipid rafts and intervenes colon carcinogenesis. *Biochem. Biophys. Res. Commun*., 529: 854-860, 2020. [PubMed]
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） Narita K, Nagatomo H, Kozuka-Hata H, Oyama M, and Takeda S. Discovery of a vertebrate-specific factor that processes flagellar glycolytic enolase during motile ciliogenesis. *iScience*, 23: 100992, 2020. [PubMed]
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） Tsuboyama K, Osaki T, Matsuura-Suzuki E, Kozuka-Hata H, Okada Y, Oyama M, Ikeuchi Y, Iwasaki S, and Tomari Y. A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation. *PLoS Biol.*,18: e3000632, 2020 [PubMed]
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） Kozuka-Hata H, Kitamura A, Hiroki T, Aizawa A, Tsumoto K, Inoue JI, and Oyama M. System-Wide Analysis of Protein Acetylation and Ubiquitination Reveals a Diversified Regulation in Human Cancer Cells. *Biomolecules*, 10: pii: E411, 2020 [PubMed]
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） Tatebayashi K, Yamamoto K, Tomida T, Nishimura A, Takayama T, Oyama M, Kozuka-Hata H, Adachi-Akahane S, Tokunaga Y, and Saito H. Osmostress enhances activating phosphorylation of Hog1 MAP kinase by mono-phosphorylated Pbs2 MAP2K. *EMBO J.*, 39: e103444, 2020. [PubMed]
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） Aoki M, Koga K, Miyazaki M, Hamasaki M, Koshikawa N, Oyama M, Kozuka-Hata H, Seiki M, Toole BP, and Nabeshima K. CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts. *BMC Cancer*, 19: 912, 2019. [PubMed]
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） Takano R, Kozuka-Hata H, Kondoh D, Bochimoto H, Oyama M, and Kato K. A High-Resolution Map of SBP1 Interactomes in Plasmodium falciparum-infected Erythrocytes. *iScience*, 19: 703-714, 2019. [PubMed]
齋尾智英（北海道大学理学研究院） Taguchi Y, Saio T, Kohda D. Distance Distribution between Two Iodine Atoms Derived from Small-Angle X-ray Scattering Interferometry for Analyzing a Conformational Ensemble of Heavy Atom-Labeled Small Molecules. J Phys Chem Lett. 2020 Jul 16;11(14):5451-5456. doi: 10.1021/acs.jpclett.0c01107. [PubMed]
齋尾智英（北海道大学理学研究院） Yoshizawa T, Nozawa RS, Jia TZ, Saio T, Mori E. Biological phase separation: cell biology meets biophysics. Biophys Rev. 2020 Apr;12(2):519-539. doi: 10.1007/s12551-020-00680-x. [PubMed]
齋尾智英（北海道大学理学研究院） Taguchi Y, Saio T, Kohda D. Distance Distribution between Two Iodine Atoms Derived from Small-Angle X-ray Scattering Interferometry for Analyzing a Conformational Ensemble of Heavy Atom-Labeled Small Molecules. J Phys Chem Lett. 2020 Jul 16;11(14):5451-5456. doi: 10.1021/acs.jpclett.0c01107. [PubMed]
齋尾智英（北海道大学理学研究院） Yoshizawa T, Nozawa RS, Jia TZ, Saio T, Mori E. Biological phase separation: cell biology meets biophysics. Biophys Rev. 2020 Apr;12(2):519-539. doi: 10.1007/s12551-020-00680-x. [PubMed]
幸福裕（東京大学・薬学研） Mizumura T, Kondo K, Kurita M, Kofuku Y, Natsume M, Imai S, Shiraishi Y, Ueda T, Shimada I. Activation of adenosine A2A receptor by lipids from docosahexaenoic acid revealed by NMR. *Science Advances*, 6, eaay8544, doi. 10.1126/sciadv.aay8544, 2020
幸福裕（東京大学・薬学研） Imai S, Yokomizo T, Kofuku Y, Shiraishi Y, Ueda T, Shimada I. Structural equilibrium underlying ligand-dependent activation of b2-adrenoreceptor. *Nature Chemical Biology* 16, 430, doi. 10.1038/s41589-019-0457-5, 2020
幸福裕（東京大学・薬学研） Terashima Y, Toda E, Itakura M, Otsuji M, Yoshinaga S, Okumura K, Shand FHW, Komohara Y, Takeda M, Kokubo K, Chen MC, Yokoi S, Rokutan H, Kofuku Y, Ohnishi K, Ohira M, Iizasa T, Nakano H, Okabe T, Kojima H, Shimizu A, Kanegasaki S, Zhang MR, Shimada I, Nagase H, Terasawa H, Matsushima K. Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties. *Nature Communications* 11, 609, doi: 10.1038/s41467-020-14338-5, 2020
幸福裕（東京大学・薬学研） Ueda T, Kofuku Y, Okude J, Imai S, Shiraishi Y, Shimada I. Function-related conformational dynamics of G protein-coupled receptors revealed by NMR *Biophysical Reviews* 11, 409, doi. 10.1007/s12551-019-00539-w, 2019
富岡征大（東京大学・理学系） Nagashima T, Iino Y, Tomioka M. DAF-16/FOXO promotes taste avoidance learning independently of axonal insulin-like signaling. *PLoS Genet* 15(7): e1008297, doi: 10.1371/journal.pgen.1008297, 2019.
富岡征大（東京大学・理学系） Jang MS, Toyoshima Y, Tomioka M, Kunitomo H, Iino Y. Multiple sensory neurons mediate starvation-dependent aversive navigation in Caenorhabditis elegans. *PNAS* 116(37), 18673-18683, doi: 10.1073/pnas.1821716116, 2019.
富岡征大（東京大学・理学系） Kumar A, Baruah A, Tomioka M, Iino Y, Kalita MC, Khan M. Caenorhabditis elegans: a model to understand host-microbe interactions. *Cellular and Molecular Life Sciences* 77: 1229–1249, doi: 10.1007/s00018-019-03319-7, 2020
道上達男（東京大学・総合文化研究科） Yokote N, Suzuki-Kosaka MY, Michiue T, Hara T, Tanegashima K. Latrophilin2 is involved in neural crest cell migration and placode patterning in Xenopus laevis. Int. J. Dev. Biol. 63: 29-35. 2019.
大戸梅治（東京大学・薬学研） Kanoh, H., Nitta, T., Go, S., Inamori, K. I., Veillon, L., Nihei, W., Fujii, M., Kabayama, K., Shimoyama, A., Fukase, K., Ohto, U., Shimizu, T., Watanabe, T., Shindo, H., Aoki, S., Sato, K., Nagasaki, M., Yatomi, Y., Komura, N., Ando, H., Ishida, H., Kiso, M., Natori, Y., Yoshimura, Y., Zonca, A., Cattaneo, A., Letizia, M., Ciampa, M., Mauri, L., Prinetti, A., Sonnino, S., Suzuki, A. & Inokuchi, J. I. Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity *EMBO J*., Jun 17;39(12):e101732. doi: 10.15252/embj.2019101732, 2019
大戸梅治（東京大学・薬学研） Jiang, S., Tanji, H., Yin, K., Zhang, S., Sakaniwa, K., Huang, J., Yang, Y., Li, J., Ohto, U., Shimizu, T. & Yin, H. H. Rationally designed small-molecule inhibitors targeting an unconventional pocket on the TLR8 protein-protein interface *J Med Chem*., Apr 23;63(8):4117-4132. doi: 10.1021/acs.jmedchem.9b02128, 2019
大戸梅治（東京大学・薬学研） Okuno, T., Koutsogiannaki, S., Hou, L., Bu, W., Ohto, U., Eckenhoff, R. G., Yokomizo, T. & Yuki, K. Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system, *FASEB J.*, 33, 14528-14541, 2019
嘉村巧（名古屋大学・理学系） Okumura F, Fujiki Y, Oki N, Osaki K, Nishikimi A, Fukui Y, Nakatsukasa K, and Kamura T. Cul5-type Ubiquitin Ligase KLHDC1 Contributes to the Elimination of Truncated SELENOS Produced by Failed UGA/Sec Decoding. *iScience* 23, 100970, doi. 10.1016/j.isci.2020.100970, 2020
嘉村巧（名古屋大学・理学系） Obara K, Kotani T, Nakatogawa H, Kihara A, and Kamura T. N-glycosylation of Rim21 at an Unconventional Site Fine-tunes Its Behavior in the Plasma Membrane. *Cell Struct Funct* 45, 1-8. doi, 10.1247/csf.19021, 2020
花房洋（名古屋大学・理学系） Hanafusa H, Yagi T, Ikeda H, Hisamoto N, Nishioka T, Kaibuchi K, Shirakabe K, and Matsumoto K. LRRK1 phosphorylation of Rab7 at S72 links trafficking of EGFR-containing endosomes to its effector RILP. *J. Cell Sci.,* 132, jcs228809 doi: 10.1242/jcs.228809, 2019
花房洋（名古屋大学・理学系） Sakai Y#, Hanafusa H#, Pastuhov SI, Shimizu T, Li C, Hisamoto N, and Matsumoto K. TDP2 negatively regulates axon regeneration by inducing SUMOylation of an Ets transcription factor. *EMBO Rep.,* 20, e47517, doi: 10.15252/embr.201847517, 2019 # equal contribution
花房洋（名古屋大学・理学系） Hisamoto N, Shimizu T, Asai K, Sakai Y, Pastuhov SI, Hanafusa H, and Matsumoto K. C. elegans Tensin promotes axon regeneration by linking the Met-like SVH-2 and Integrin signaling pathways. *J. Neurosci.,* 39, 5662-5672, doi: 10.1523/JNEUROSCI.2059-18, 2019
2019.8.14	井上純一郎（東京大学医科学研究所・分子発癌分野） Yamamoto, M., Abe, C., Wakinaga, S., Sakane, K., Yumiketa, Y., Taguchi, Y., Matsumura, T., Ishikawa, K., Fujimoto, J., Semba, K., Miyauchi, M., Akiyama, T. and Inoue, J.* TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion. *Communications Biology* 2, Article number: 292 (2019). https://doi.org/10.1038/s42003-019-0547-7[PubMed]
	井上純一郎（東京大学医科学研究所・分子発癌分野） Hatanaka, N., Seki, T., Inoue, J., Tero, A. and Suzuki, T.* Critical roles of IkBa and RelA phosphorylation in transitional oscillation in NF-κB signaling module. *J. Theor. Biol.* 462, 479-489 (2019). doi: 10.1016/j.jtbi.2018.11.023. [PubMed]
	井上純一郎（東京大学医科学研究所・分子発癌分野） Yamamoto, M., Du, Q., Song, J., Wang, H., Watanabe, A., Tanaka, Y., Kawaguchi, Y., Inoue, J.* and Matsuda, Z.* Cell-cell and virus-cell fusion assay-based analyses of alanine insertion mutants in the distal α9 portion of the JRFL gp41 subunit from HIV-1. *J. Biol. Chem.* 294(14), 5677-5687 (2019). doi: 10.1074/jbc.RA118.004579.[PubMed]
	井上純一郎（東京大学医科学研究所・分子発癌分野） Radwan, M.O., Koga, R., Hida, T., Ejima, T., Kanemaru, Y., Tateishi, H., Okamoto, Y., Inoue, J., Fujita, M. and Otsuka, M.* Minimum structural requirements for inhibitors of the zinc finger protein TRAF6. *Bioorg*. Med. Chem. Lett. 29, 2162-2167 (2019). https://doi.org/10.1016/j.bmcl.2019.06.050 [PubMed]
	井上純一郎（東京大学医科学研究所・分子発癌分野） Kajikawa, S., Taguchi, Y., Hayata, T., Ezura, Y., Ueta, R., Arimura, S., Inoue, J., Noda, M. and Yamanashi, Y.* Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia. Biochem. Biophys. Res. Commun. 498, 967-974. (2018) doi: 10.1016/j.bbrc.2018.03.090.[PubMed]
	井上純一郎（東京大学医科学研究所・分子発癌分野） Liu, D., Wang, H., Yamamoto, M., Song, J., Zhang, R., Du, Q., Kawaguchi, Y., Inoue, J. and Matsuda, Z.* Six-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection. *Retrovirology* (2018) 15:27. doi: 10.1186/s12977-018-0410-9 [PubMed]
	井上純一郎（東京大学医科学研究所・分子発癌分野） Ogawa, M., Matsuda, R., Takada, N., Tomokiyo, M., Yamamoto, S., Shizukusihi, S., Yamaji, T., Yoshikawa, Y., Yoshida, M., Tanida, I., Koike, M., Murai, M., Morita, H., Takeyama, H., Ryo, A., Guan, J.-L., Yamamoto, M., Inoue, J., Yanagawa, T., Fukuda, M., Kawabe, H. and Ohnishi, M. Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination. *Cell Microbiol.* (2018) 26:e12846. doi: 10.1111/cmi.12846. [PubMed]
	井上純一郎（東京大学医科学研究所・分子発癌分野） Johmura, Y., Maeda, I., Suzuki, N., Wu, W., Goda, A., Morita, M., Yamaguchi, K., Yamamoto, M., Nagasawa, S., Kojima, Y., Tsugawa, K., Inoue, N., Miyoshi, Y., Osako, T., Akiyama, F., Maruyama, R., Inoue, J., Furukawa, Y., Ohta, T and Nakanishi, M.* Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer. *J. Clin. Invest.* 128, 5603-5619 (2018). doi: 10.1172/JCI121679.[PubMed]
	井上純一郎（東京大学医科学研究所・分子発癌分野） Inuki, S., Aiba, T., Kawakami,S., Akiyama, T., Inoue, J. and Fujimoto, Y.* Total synthesis of D-glycero-D-manno-Heptose 1,7-Bisphosphate and evaluation of its ability to modulate NF-κB Activation. *Org. Lett.* 19, 3079-3082 (2017). doi: 10.1021/acs.orglett.7b01158. [PubMed]
	井上純一郎（東京大学医科学研究所・分子発癌分野） Koga, R., Radwan, M.O., Ejima, T., Kanemaru, Y., Tateishi, H., Ali, T.F.C., Ciftci, H.I., Shibata, Y., Taguchi, Y., Inoue, J., Otsuka M. and Fujita, M.* A Dithiol Compound Binds to the Zinc Finger Protein TRAF6 and Suppresses its Ubiquitination. *ChemMedChem* 12, 1935-1941 (2017). doi:10.1002/cmdc.201700399. [PubMed]
2018.11.19	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Kasuya G, Ishitani R, Tokunaga F, Nureki O Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1. *Nat Commun*. 9(1):4424 (2018). [PubMed]
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Oikawa D, Shiota M, Goto E, Komakura K, Wanibuchi H, Tokunaga F. Generation of Rat Monoclonal Antibodies Against a Deubiquitinase, Ovarian Tumor Domain-Containing Protein 1.Monoclon Antib Immunodiagn Immunother. 37(4):180-184 (2018). [PubMed]
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M. High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors Using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System. *SLAS Discov.* 2:2472555218793066 (2018). [PubMed]
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Oikawa D, Shiota M, Tokunaga F, Wanibuchi H. Generation of rat monoclonal antibodies specific for DZIP3. *Monoclon. Antib. Immunodiagn. Immunother.*37(3)157-157 (2018) [PubMed]
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki SI, Wakamatsu K, Tokunaga F, Shimizu A. In-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.J. Dermatol. Sci. 91(1) 35-42 (2018) [PubMed]
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Kuriyama Y, Hattori M, Mitsui T, Nakano H, Oikawa D, Tokunaga F, Ishikawa O, Shimizu A. Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency. J. Dermatol. 45(5), e108-e109 (2018) [PubMed]
2018.8.29	井上純一郎（東京大学医科学研究所・分子発癌分野） Gohda J, Suzuki K, Liu K, Xie X, Takeuchi H, Inoue J, Kawaguchi Y and Ishida T. BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1. Sci. Rep.* 8:3521 (2018).
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Maruyama T, Imai S, Kusakizako T, Hattori M, Ishitani R, Nureki O, Ito K, Maturana AD, Shimada I and Osawa M. Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR. eLife 7, e31596 (2018)
	武川睦寛（東京大学医科学研究所・分子シグナル制御分野） ◎▲Iijima M, Kubota Y, Sawa R, Kubota Y, Hatano M, Arashi M, Kawada M, Momose I, Takekawa M and Shibasaki M. A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. J Antibiot, 71, 135–138 (2018)
	武川睦寛（東京大学医科学研究所・分子シグナル制御分野） Ichimanda M, Hijiya N, Tsukamoto Y, Uchida T, Nakada, C, Akagi T, Etoh T, Iha H, Inomata M, Takekawa M and ＊Moriyama M. Downregulation of DUSP4 enhances cell proliferation and invasiveness in colorectal carcinomas. Cancer Sci. 109, 250-258 (2018).
	上野　匡（東京大学大学院薬学系研究科・薬品代謝化学教室） ◎▲Taguchi R., Terai T., Ueno T., Komatsu T., Hanaoka K., Urano Y. A Protein-Coupled Fluorescent Probe For Organelle-Specific Imaging of Na+. Sens Act B Chem* 265, 575-581 (2018)
	上野　匡（東京大学大学院薬学系研究科・薬品代謝化学教室） ◎▲Kuriki Y, Kamiya M, Kubo H, Komatsu T, Ueno T, Tachibana R, Hayashi K, Hanaoka K, Yamashita S, Ishizawa T, Kokudo N & Urano Y. Establishment of Molecular Design Strategy to Obtain Activatable Fluorescent Probes for Carboxypep. J Am Chem Soc* 140, 1767-1773 (2018)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） ◎▲Taniguchi R, Inoue A, Sayama M, Uwamizu A, Yamashita K, Hirata K, Yoshida M, Tanaka Y, Kato E, Nakada Y, Otani Y, Nishizawa T, Ohwada T, Ishitani R, Aoki J, Nureki O. Structural insights into ligand recognition by the lysophosphatidic acid R LPA6. Nature 548, 356-360 (2017)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Yamano T, Zetsche B, Ishitani R, Zhang F, Nishimasu H, *Nureki O. Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1. Mol. Cell 67 633-645 (2017)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Yamada M, Watanabe Y, Gootenberg JS, Hirano H, Ran FA, Nakane T, Ishitani R, Zhang F, Nishimasu H, Nureki O. Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems. Mol Cell 65, 1109-1121 (2017)
	井上純一郎（東京大学医科学研究所・分子発癌分野） ◎▲Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K and *Inoue J. HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. PLoS Pathog 13(1):e1006162 (2017).
	武川睦寛（東京大学医科学研究所・分子シグナル制御分野） ◎▲Kubota Y, Fujioka K and Takekawa M. WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins. PLoS ONE* 12: e0180714. doi.org/10.1371/journal.pone.0180714 (2017)
	武川睦寛（東京大学医科学研究所・分子シグナル制御分野） ◎▲Kubota Y and *Takekawa M. Detection and functional analysis of SUMO-modified MEK. Methods Mol Biol 1487, 99-111, (2017)
	井上純一郎（東京大学医科学研究所・分子発癌分野） Magilnick N, Reyes EY, Wang WL, Vonderfecht S, Gohda J, Inoue J, Boldin MP. The miR-146a-Traf6 regulatory axis controls autoimmunity and myelopoiesis, but is dispensable for hematopoietic stem cell homeostasis and tumor suppression. Proc Natl Acad Sci USA* 114, 7140-7149 (2017).
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Nishimasu H, Yamano T, Gao L, Zhang F, Ishitani R, Nureki O. Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf1. Mol. Cell* 67, 139-147 (2017)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） ◎Miyauchi H, Moriyama S, Kusakizako T, Kumazaki K, Nakane T, Yamashita K, Hirata K, Dohmae N, Nishizawa T, Ito K, Miyaji T, Moriyama Y, Ishitani R, Nureki O. Structural basis for xenobiotic extrusion by eukaryotic MATE transporter. Nat Commun. 8, 1633 (2017)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Tomita A, Zhang M, Jin F, Zhuang W, Takeda H, Maruyama T, Osawa M, Hashimoto KI, Kawasaki H, Ito K, Dohmae N, Ishitani R, Shimada I, Yan Z, Hattori M, Nureki O ATP-dependent modulation of MgtE in Mg2+ homeostasis. Nat Commun.* 8, 148 (2017)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Kasuya G, Yamaura T, Ma XB, Nakamura R, Takemoto M, Nagumo H, Tanaka E, Dohmae N, Nakane T, Yu Y, Ishitani R, Matsuzaki O, Hattori M, Nureki O. Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel. Nat Commun.* 8, 876 (2017)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Lee Y, Nishizawa T, Takemoto M, Kumazaki K, Yamashita K, Hirata K, Minoda A, Nagatoishi S, Tsumoto K, Ishitani R, Nureki O. Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity. Nat Plants* 3, 825–832 (2017)
	井上純一郎（東京大学医科学研究所・分子発癌分野） Varney M, Choi K, Bolanos L, Christie S, Fang J, Grimes H.L, Maciejewski J, Inoue J and Starczynowski D. Epistasis between TIFAB and miR-146a, neighboring genes in del(5q) MDS. Leukemia* 31, 491–495 (2017).
	上野　匡（東京大学大学院薬学系研究科・薬品代謝化学教室） ◎▲Chiba M, Ichikawa Y, Kamiya M, Komatsu T, Ueno T, Hanaoka K, Nagano T, Lange N. and Urano Y. An Activatable Photosensitizer Targeted to γ-Glutamyltranspeptidase Angew Chem Int Ed* 56, 10418-10422 (2017)
	上野　匡（東京大学大学院薬学系研究科・薬品代謝化学教室） ◎▲Piao W, Hanaoka K, Fujisawa T, Takeuchi S, Komatsu T, Ueno T, Terai T, Tahara T, Nagano T. and Urano Y. Development of an Azo-based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy. J Am Chem Soc* , 139, 13713–13719 (2017)
	上野　匡（東京大学大学院薬学系研究科・薬品代謝化学教室） ◎▲Onagi J, Komatsu T, Ichihashi Y, Kuriki Y, Kamiya M, Terai T, Ueno T, Hanaoka K, Matsuzaki H, Hata K, Watanabe T, Nagano T, and Urano Y. Discovery of Cell-type-specific and Disease-related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism J Am Chem Soc* 139, 3465–3472 (2017)
	井上純一郎（東京大学医科学研究所・分子発癌分野） ◎▲Yamamoto M, Sakane K, Tominaga K, Gotoh N, Niwa T, Kikuchi Y, Tada K, Goshima N, Semba K and *Inoue J. Intratumoral bidirectional transitions between epithelial and mesenchymal cells in triple-negative breast cancer. Cancer Sci. 108, 1210-1222 (2017). doi: 10.1111/cas.13246.
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） ▲Goto E and Tokunaga F. Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP. Biochem. Biophys. Res. Commun.* 485, 152-159, (2017).
	井上純一郎（東京大学医科学研究所・分子発癌分野） Into T, Horie T, Inomata1 M, Gohda J, Inoue J, Murakami Y and Niida S. Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88. Sci. Rep.* 7: 1009 (2017).
	武川睦寛（東京大学医科学研究所・分子シグナル制御分野） ◎▲Arimoto-Matsuzaki K, Saito H and Takekawa M. TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis. Nat Commun.* 7: 10252 (2016)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Matsumoto N, Nishimasu H, Sakakibara K, Nishida KM, Hirano T, Ishitani R, Siomi H, Siomi MC, *Nureki O. Crystal Structure of Silkworm PIWIClade Argonaute Siwi Bound to piRNA. Cell 167, 484-497 (2016)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Yamano T, Nishimasu H, Zetsche B, Hirano H, Slaymaker IM, Li Y, Fedorova I, Nakane T, Makarova KS, Koonin EV, Ishitani R, Zhang F, Nureki O. Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA. Cell 165, 949-962 (2016)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Hirano H, Gootenberg JS, Horii T, Abudayyeh OO, Kimura M, Hsu PD, Nakane T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O. Structure and Engineering of Francisella novicida Cas9. Cell 164, 950-961 (2016)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Tsuchiya H, Doki S, Takemoto M, Ikuta T, Higuchi T, Fukui K, Usuda Y, Tabuchi E, Nagatoishi S, Tsumoto K, Nishizawa T, Ito K, Dohmae N, Ishitani R, Nureki O. Structural basis for amino acid export by DMT superfamily transporter YddG. Nature 534, 417-420 (2016)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Hirano S, *Nishimasu H, Ishitani R, Nureki O. Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9. Mol Cell 61, 886-894 (2016)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Morita J, Kato K, Nakane T, Kondo Y, Fukuda H, Nishimasu H, Ishitani R, Nureki O. Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide. Nat Commun. 7, 12383 (2016)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Kato K, Satouh Y, Nishimasu H, Kurabayashi A, Morita J, Fujihara Y, Oji A, Ishitani R, Ikawa M, Nureki O. Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization. Nat Commun. 7, 12198 (2016)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） ◎▲Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun.* 7, 12547 (2016)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Kato K, Ikeda H, Miyakawa S, Futakawa S, Nonaka Y, Fujiwara M, Okudaira S, Kano K, Aoki J, Morita J, Ishitani R, Nishimasu H, Nakamura Y, Nureki O. Structural basis for specific inhibition of Autotaxin by a DNA aptamer. Nat Struct Mol Biol 23, 395-401 (2016)
	井上純一郎（東京大学医科学研究所・分子発癌分野） Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger J.M, Kobayashi Y, Inoue J and Akiyama T. Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. J. Exp. Med.* 213(8):1441-58. (2016).
	徳永文稔（大阪市立大学大学院医学研究科・分子病態学） Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsnomiya A, Watanabe T and Yamaoka S. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells. Leukemia* 30,716-727, (2016).
	上野　匡（東京大学大学院薬学系研究科・薬品代謝化学教室） Kim AK, DeRose R, Ueno T, Lin B, Komatsu T, Nakamura H and Inoue T. Toward Total Synthesis of Cell Function: Reconstituting Cell Dynamics with Synthetic Biology. Sci. Signaling*, 9, re1 (2016)
	武川睦寛（東京大学医科学研究所・分子シグナル制御分野） ◎▲Hijiya N, Tsukamoto Y, Nakada C, Tung NL, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, and Moriyama M. Genomic loss of DUSP4 contributes to the progression of intraepitherial neoplasm of pancreas to invasive carcinoma. Cancer Res* 76: 2612-2625, (2016)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） ◎▲Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, Nureki O. Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide. Sci. Rep.* 6, 34756 (2016)
	武川睦寛（東京大学医科学研究所・分子シグナル制御分野） ◎Kinoshita E, Kinoshita-Kikuta E, Kubota Y, Takekawa M and Koike T. A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1. Proteomics* 16: 1825-1836, (2016)
	井上純一郎（東京大学医科学研究所・分子発癌分野） Yu J, Yun H, Shin B, Kim Y, Park E.S, Choi S, Yu J, Amarasekara D.S, Kim S, Inoue J, Walsh M.C, Choi Y, Takami M and Rho J. Interaction of tumor necrosis factor receptor-associated factor 6 (TRAF6) and Vav3 in the receptor activator of nuclear factor kB (RANK) signaling complex enhances osteoclastogenesis. J. Biol. Chem.* 291(39):20643-60. (2016)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Kasuya G, Hiraizumi M, Maturana AD, Kumazaki K, Fujiwara Y, Liu K, Nakada-Nakura Y, Iwata S, Tsukada K, Komori T, Uemura S, Goto Y, Nakane T, Takemoto M, Kato HE, Yamashita K, Wada M, Ito K, Ishitani R, Hattori M, Nureki O. Crystal structures of the TRIC trimeric intracellular cation channel orthologues. Cell Res. 26, 1288-1301 (2016)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Kasuya G, Fujiwara Y, Tsukamoto H, Morinaga S, Ryu S, Touhara K, Ishitani R, Furutani Y, Hattori M, Nureki O. Structural insights into the nucleotide base specificity of P2X receptors. Sci. Rep. 7, 45208 (2016)
	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Kasuya G, Fujiwara Y, Takemoto M, Dohmae N, Nakada-Nakura Y, Ishitani R, Hattori M, Nureki O. Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels. Cell *Rep*. 14, 932-944 (2016)
	鈴木　貴（大阪大学大学院基礎工学研究科・システム創成選考） ◎▲Suzuki T, Pierre M and Yamada Y. Dissipative reaction diffusion systems with quadratic growth. Indiana Univ. Math. J.* in press
	久保田浩行（九州大学生体防御医学研究所・統合オミクス分野） ◎▲ Kubota H, Uda S, Matsuzaki F, Yamauchi Y and Kuroda S. Selective control of the Insulin-AKT pathway by simultaneous processing of blood insulin patterns in vivo. Cell Systems. in press (2018).
	鈴木　貴（大阪大学大学院基礎工学研究科・システム創成選考） Suzuki T, Dhisa M, Nishiyama K, Koshikawa N and Chaplain M. Study on the tumor-induced angiogenesis using mathematical models. Cancer Science* (2018) 15-23, DOI:10.1111/cas.13395(2018)
	鈴木　貴（大阪大学大学院基礎工学研究科・システム創成選考） ◎▲*Suzuki T, Kobayashi M and Yamada Y. Lotka-Volterra systems with periodic orbits, Funkcialaj Ekvacioj 61 (2018)
	鈴木　貴（大阪大学大学院基礎工学研究科・システム創成選考） ◎▲Suzuki T and Sasaki T. Asymptotic behaviour of the solution to a virus dynamics model with diffusion. DCDS-B* , ABNS 23(2), 525-541, doi:10.3934/dcdsb.2017206 (2018)
	久保田浩行（九州大学生体防御医学研究所・統合オミクス分野） ◎▲ Tsucguya T, Fujii M, Matsuda N, Kunida K, Uda S, Kubota H, Konishi K and Kuroda S. System identification of signaling dependent gene expression with different time-scale data. PLoS Comput. Biol.* 13(12): e1005913 (2017).
	鈴木　貴（大阪大学大学院基礎工学研究科・システム創成選考） Suzuki T, Pierre M and Umakoshi H. Global-in-time behavior of weak solution to reaction diffusion system with inhomogeneous Dirichlet boundary condition. Nonlinear Anal.* TMA 159 ,393-407. DOI. 10.1016/j.na.2017.01.013(2017)
	鈴木　貴（大阪大学大学院基礎工学研究科・システム創成選考） Suzuki T and Espejo E. Reaction enhancement by chemotaxis in a model describing fertitization of corals. Nonlinear Analysis: Real World Applications* 35 ,102-131. (2017)
	鈴木　貴（大阪大学大学院基礎工学研究科・システム創成選考） ◎▲Kawasaki S, Minerva D, Itano K and Suzuki T. Finding solvable units of variables in nonlinear ODEs of ECM degradation pathway network. Comp. Math. Mech. Medicine.*, 1-15, ID5924270. Open https://doi.org/10.1155/2017/5924270 , (2017)
	鈴木　貴（大阪大学大学院基礎工学研究科・システム創成選考） Suzuki T, Pierre M and Zou R. Asymptotic behavior of renormalized solution to chemical reaction diffusion systems. JMAA* , 450 (1), 152-168, DOI. 10.1016/j.jmaa.2017.01.022, (2017)
	鈴木　貴（大阪大学大学院基礎工学研究科・システム創成選考） *Suzuki Y and Kavallaris N.I. A non-local parabolic equation associated with Gierer-Meinhardt system Nonlinearity. NON-101571.R1 (2017)
	鈴木　貴（大阪大学大学院基礎工学研究科・システム創成選考） Gallinato O, Ohta M, Poignard C and Suzuki T. Free boundary problem for cell protrusion formations. J. Math.* Biol. 1-45 (2016)
	澤崎達也（愛媛大学　プロテオサイエンスセンター） ◎▲Nemoto K, Kagawa M, Nozawa A, Hasegawa Y, Hayashi M, Imai K, Tomii K and Sawasaki T. Identification of new abscisic acid receptor agonists using a wheat cell-free based drug screening system. Sci Rep.* 2018 Mar 9;8(1):4268. doi: 10.1038/s41598-018-22538-9. (2018)
	尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） ◎▲Fujita T#, Kozuka-Hata H# (#; equal contribution), Hori Y, Takeuchi J, Kubo T and Oyama M. Shotgun proteomics deciphered age/division of labor-related functional specification of three honeybee (Apis mellifera L.) exocrine glands. PLoS ONE , 13, e0191344 (2018).
	澤崎達也（愛媛大学　プロテオサイエンスセンター） ◎▲Uematsu A, Kido K, Manabe E, Takeda H, Takahashi H, Hayashi M, Imai Y and Sawasaki, T. DANFIN functions as an inhibitor of transcription factor NF-κB and potentiates the antitumor effect of bortezomib in multiple myeloma. Biochem Biophys Res Commun* . 495(3):2289-2295. doi: 10.1016/j.bbrc.2017.12.142. (2018)
	尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） ◎Inoue D, Fujino T, Sheridan P, Zhang Y.Z, Nagase R, Horikawa S, Li Z, Matsui H, Kanai A, Saika M, Yamaguchi R, Kozuka-Hata H, Kawabata K, Yokoyama A, Goyama S, Inaba T, Imoto S, Miyano S, Xu M, Yang F.C, Oyama M and Kitamura T. A novel ASXL1–OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies. Leukemia , doi:10.1038/s41375-018-0083-3 (2018).
	尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） ◎Kikuchi K, Kozuka-Hata H, Oyama M, Seiki M and Koshikawa N. Identification of Proteolytic Cleavage Sites of EphA2 by Membrane Type 1 Matrix Metalloproteinase on the Surface of Cancer Cells. Methods Mol. Biol.* , 1731, 29-37 (2018).
	澤崎達也（愛媛大学　プロテオサイエンスセンター） Miura T, Takeo S, Ntege E.H, Otsuki H, Sawasaki T, Ishino T, Takashima E and Tsuboi T. The malaria parasite RhopH protein complex interacts with erythrocyte calmyrin identified from a comprehensive erythrocyte protein library. Biochem Biophys Res Commun* . 500(2):261-267.(2018)
	澤崎達也（愛媛大学　プロテオサイエンスセンター） ◎▲Nemoto K, Ramadan A, Arimura G.I, Imai K, Tomii K, Shinozaki, K and Sawasaki, T. Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation. Nat Commun.* 8(1):1004. doi: 10.1038/s41467-017-01005-5. (2017)
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） ◎Saitoh S.I, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K and Miyake K. TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells. Nat. Commun.*, 8, 1592 (2017).
澤崎達也（愛媛大学　プロテオサイエンスセンター） ◎▲Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K and *Inoue J. HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains. PLoS Pathog. 13, e100162, (2017).
澤崎達也（愛媛大学　プロテオサイエンスセンター） ◎▲Takeda H, Zhou W, Kido K, Suno R, Iwasaki T, Kobayashi T and Sawasaki, T. CP5 system, for simple and highly efficient protein purification with a C-terminal designed mini tag. PLoS ONE* . 12(5):e0178246. doi: 10.1371/journal.pone.0178246. (2017)
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） ◎Contu V.R, Hase K, Kozuka-Hata H, Oyama M, Fujiwara Y, Kabuta C, Takahashi M, Hakuno F, Takahashi S.I, Wada K and Kabuta T. Lysosomal targeting of SIDT2 via multiple YxxΦ motifs is required for SIDT2 function in the process of RNautophagy. J. Cell* Sci., 130, 2843-2853 (2017).
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） ◎Suzawa M, Noguchi K, Nishi K, Kozuka-Hata H, Oyama M and Ui-Tei K. Comprehensive Identification of Nuclear and Cytoplasmic TNRC6AAssociating Proteins. J. Mol. Biol.*, 429, 3319-3333 (2017).
澤崎達也（愛媛大学　プロテオサイエンスセンター） Sun S, Nakashima K, Ito M, Li Y, Chida T, Takahashi H, Watashi K, Sawasaki T, Wakita T and Suzuki T. Involvement of PUF60 in Transcriptional and Post-transcriptional Regulation of Hepatitis B Virus Pregenomic RNA Expression. Sci Rep.* 7(1):12874. (2017)
澤崎達也（愛媛大学　プロテオサイエンスセンター） Yonezawa T, Takahashi H, Shikata S, Liu X, Tamura M, Asada S, Fukushima T, Fukuyama T, Tanaka Y, Sawasaki T, Kitamur, T and Goyama, S. The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1. J Biol Chem.* 292(30):12528-12541. (2017)
澤崎達也（愛媛大学　プロテオサイエンスセンター） Liu S, Hasegawa H, Takemasa E, Suzuki Y, Oka K, Kiyoi T, Takeda H, Ogasawara T, Sawasaki T, Yasukawa M and Maeyama K. Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models. J Immunol.* 199:1584-1595. doi: 10.4049/jimmunol.1700192. (2017)
澤崎達也（愛媛大学　プロテオサイエンスセンター） Yamamoto T, Taira-Nihira N, Yogosawa S, Aoki K, Takeda H, Sawasaki T and *Yoshida K. Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks. FEBS Lett. 591(6):842-853. doi: 10.1002/1873-3468.12596. (2017)
澤崎達也（愛媛大学　プロテオサイエンスセンター） Hashimoto Y, Shirakura K, Okada Y, Takeda H, Endo K, Tamura M, Watari A, Sadamura Y, Sawasaki T, Doi T, Yagi K and Kondoh, M. Claudin-5- binders enhance permeation of solutes across the blood-brain barrier in a mammalian model. J Pharmacol Exp Ther.* 363(2):275-283.(2017)
澤崎達也（愛媛大学　プロテオサイエンスセンター） ◎▲Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O and Tokunaga F. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun*. 7:12547. doi: 10.1038/ncomms12547. (2016)
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） ◎Hashimoto T, Horikawa D.D, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T, Enomoto A, Kondo K, Tanaka S, Hara Y, Koshikawa S, Sagara H, Miura T, Yokobori S, Miyagawa K, Suzuki Y, Kubo T, Oyama M, Kohara Y, Fujiyama A, Arakawa K, Katayama T, Toyoda A and Kunieda T. Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. Nat Commun., 7, 12808 (2016).􀀃
澤崎達也（愛媛大学　プロテオサイエンスセンター） Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T and Yamashita M. Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop. Nat Commun.* 7:12596. doi: 10.1038/ncomms12596. (2016)
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） ◎▲Narushima Y, Kozuka-Hata .H, Tsumoto K, Inoue J and Oyama M. Quantitative phosphoproteomics-based molecular network description for high-resolution kinase-substrate interactome analysis. Bioinformatics*, 32, 2083-2088 (2016).
澤崎達也（愛媛大学　プロテオサイエンスセンター） ◎▲Yano T, Takeda H, Uematsu A, Yamanaka S, Nomura S, Nemoto K, Iwasaki T, Takahashi H and Sawasaki T. AGIA Tag System Based on a High Affinity Rabbit Monoclonal Antibody against Human Dopamine Receptor D1 for Protein Analysis. PLoS ONE* . 11(6):e0156716. (2016)
尾山大明（東京大学医科学研究所・疾患プロテオミクスラボラトリー） ◎Hirano A, Nakagawa T, Yoshitane H, Oyama M, Kozuka-Hata H, Lanjakornsiripan D and Fukada Y. USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock. PLoS ONE* , 11, e0154263 (2016).
澤崎達也（愛媛大学　プロテオサイエンスセンター） Takahashi H, Uematsu A, Yamanaka S, Imamura M, Nakajima T, Doi K, Yasuoka S, Takahashi C, Takeda H and Sawasaki T. Establishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate Proteins. PLoS ONE* . 11(6):e0156718. doi: 10.1371/journal.pone.0156718. (2016)
澤崎達也（愛媛大学　プロテオサイエンスセンター） Santolini M, Sakakibara I, Gauthier M, Ribas F, Takahashi H, Sawasaki T, Mouly V, Concordet J.P, Defossez P.A, Hakim V and Maire P. MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis. Nucleic Acids Res.* 44(18):8621-8640. (2016)
澤崎達也（愛媛大学　プロテオサイエンスセンター） Ogawa S, Miyamoto K, Nemoto K, Sawasaki T, Yamane H, Nojiri H and Okada K. OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability. Sci Rep.* 7:40175. doi: 10.1038/srep40175. (2016)
澤崎達也（愛媛大学　プロテオサイエンスセンター） Takagi M, Sakamoto T, Suzuki R, Nemoto K, Obayashi T, Hirakawa T, Matsunaga T.M, Kurihara D, Nariai Y, Urano T, Sawasaki T and Matsunaga S.􀀃 Plant Aurora kinases interact with and phosphorylate transcription factors. J Plant Res.* 129(6):1165-1178. (2016)
澤崎達也（愛媛大学　プロテオサイエンスセンター） Sakamaki K, Ishii T.M, Sakata T, Takemoto K, Takagi C, Takeuchi A, Morishita R, Takahashi H, Nozawa A, Shinoda H, Chiba K, Sugimoto H, Saito A, Tamate S, Satou Y, Jung S,K, Matsuoka S, Koyamada K, Sawasaki T, Nagai T and Ueno N. Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage. Biochim Biophys Acta.* pii: S0167-4889(16)30215-4. doi: 10.1016/j.bbamcr.2016.08.010. (2016)
仁科博史（東京医科歯科大学・難治疾患研究所） Tokiwa Yamasaki, Norie Deki-Arima, Asahito Kaneko, Norio Miyamura, Mamiko Iwatsuki, Masato Matsuoka, Noriko Fujimori-Tonou, Yoshimi Okamoto-Uchida, Jun Hirayama, Jamey D. Marth, Yuji Yamanashi, Hiroshi Kawasaki, Koji Yamanaka, Josef M. Penninger, Shigenobu Shibata and Hiroshi Nishina (2017) Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Scientific Reports 7, 7348.
大戸梅治（東京大学・薬学研） Ohto, U., Ishida, H., Shibata, T., Sato, R., Miyake, K., Shimizu, T. "Two DNA binding sites on Toll-like receptor 9 function cooperatively in receptor activation" Immunity* 48, 649-658 (2018)
大戸梅治（東京大学・薬学研） Miyake, K., Shibata, T., Ohto, U., Shimizu, T., Saitoh, S. I., Fukui, R., Murakami, Y. "Mechanisms controlling nucleic acid-sensing Toll-like receptors" Int Immunol.* 30, 43-51 (2018)
大戸梅治（東京大学・薬学研） Zhang, S., Hu, Z., Tanji, H., Jiang, S., Das, N, Li, J., Sakaniwa, K., Jin, J., Bian, Y., Ohto, U., Shimizu, T., Yin, H. "Small-molecule inhibition of TLR8 through stabilization of its resting state" Nature Chem. Biol. 14, 58-64 (2018)
本田信治（福井大学・医学部） Jamieson K, McNaught KJ, Ormsby T, Leggett NA, Honda S, and ＊Selker EU. Telomere repeats induce domains of H3K27 methylation in Neurospora *eLife* 7, e31216 (2018) . 査読有
五島剛太（名古屋大学・理学系） Leong SY, Yamada M, Yanagisawa N, Goshima G. SPIRAL2 stabilises endoplasmic microtubule minus ends in the moss Physcomitrella patens. Cell Struct Funct.* 43(1), 53-60 (2018). 査読有
花房洋（名古屋大学・理学系） Hisamoto, N., Tsuge, A., Pastuhov, S., Shimizu, T., Hanafusa, H. and Matsumoto, K. Phosphatidylserine exposure mediated by ABC transporter activates the integrin signaling pathway promoting axon regeneration. Nature Commun.* in press査読有
花房洋（名古屋大学・理学系） Shimizu, T., Pastuhov, S., Hanafusa, H., Matsumoto, K. and Hisamoto, N. The C. elegans BRCA2-ALP/Enigma complex regulates axon regeneration via a Rho GTPase-ROCK-MLC phosphorylation pathway. Cell Reports* in press 査読有
藤田宏明（京都大学・医学系研） Fujita H, Tokunaga A, Shimizu S, Whiting AL, Aguilar-Alonso F, Takagi K, Walinda E, Sasaki Y, Shimokawa T, Mizushima T, Ohki I, Ariyoshi M, Tochio H, Bernal F, Shirakawa M, and Iwai K., Cooperative domain formation by homologous motifs in HOIL-1L and SHARPIN plays crucial roles in LUBAC stabilization. Cell reports*, 23(4), 1192-1204 (2018) 査読有
岡田雅人（大阪大学・微生物病研究所） Tsukamoto T, Kajiwara K, Nada S, Okada M. Src mediates TGF-β–induced intraocular pressure elevation in glaucoma. J Cell Physiol*. in press. (2018)査読有
岡田雅人（大阪大学・微生物病研究所） Hayama Y, Kimura T, Takeda Y, Nada S, Koyama S, Takamatsu H, Kang S, Ito D, Maeda Y, Nishide M, Nojima S, Sarashina-Kida H, Hosokawa T, Kinehara Y, Kato Y, Nakatani T, Nakanishi Y, Tsuda T, Koba T, Okada M, and Kumanogoh A. Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB. *J Immunol.* 200: 3790-3800 (2018) 査読有
岡田雅人（大阪大学・微生物病研究所） Hao F, Kondo K, Itoh T, Ikari S, Nada S, Okada M, Noda T. Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi-lysosome contact site. J Cell Sci*. 131, 208017 (2018) 査読有
松本雅記（九州大学・生体研） Watanabe, S., Fujiyama, H., Takafuji, T., Kayama, K, Matsumoto, M., Nakayama, K.I., Yoshida, K., Sugimoto, N., Fujita, M. Glutamate-rich WD40 repeat containing 1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system. *J Cell Sci.* pii: jcs.213009 (2018) . 査読あり
松本雅記（九州大学・生体研） Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K.I., Cohen, S.M., Tanaka, T., Rothenberg, E.V. Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding. *Immunity* 48, 1119-1134 (2018). 査読あり
松本雅記（九州大学・生体研） Morita, M., Sato, T, Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A., Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K.I., Watanabe, T., Soga, T., Shima, H., Maemondo, M., and Tanuma, N. PKM1 confers metabolic advantages and promotes cell-autonomous tumor cell growth. Cancer Cell* 33,355-367 (2018). 査読あり
橋本博（静岡県立大学・薬学部） Hara, K., Uchida, M., Tagata, R., Yokoyama, H., Ishikawa, Y., Hishiki, A. and Hashimoto, H. Structure of proliferating cell nuclear antigen (PCNA) bound to AlkB homolog 2 PCNA-binding motif (APIM) reveals universality of PCNA-interaction. Acta Crystallogr. F*74, 214-221 (2018). 査読有
橋本博（静岡県立大学・薬学部） Kishimoto S, Hara K, Hashimoto H, Hirayama Y, Champagne PA, Houk KN, Tang Y, Watanabe K. Enzymatic one-step ring contraction for quinolone biosynthesis.　 Nat Commun. 2018 Jul 19;9(1):2826. doi: 10.1038/s41467-018-05221-5.
高橋明格（沖縄科学技術大学院大学） Yamaguchi, T., Suzuki, T., Sato, T., Takahashi, A., Watanabe, H., Kadowaki, A., Natsui, M., Inagaki, H., Arakawa, S., Nakaoka, S., Koizumi, Y., Seki, S., Adachi, S., Fukao, A., Fujiwara, T., Natsume, T., Kimura, A., Komatsu, M., Shimizu, S., Ito, H., Suzuki, Y., Penninger, J.M., Yamamoto, T., Imai, Y., Kuba, K. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci. Signal. 11, pii: eaan3638. doi: 10.1126/scisignal.aan3638. (2018). 査読有
伊東剛（東京大学・医科学研究所） Ito T, Kasai Y, Kumagai Y, Suzuki D, Ochiai-Noguchi M, Irikura D, Miyake S, Murakami Y. Quantitative analysis of interaction between CADM1 and its binding cell-surface proteins using surface plasmon resonance imaging. *Front Cell Dev Biol, 6: 86, 2018. (in press*) 査読有 doi: 10.3389/fcell.2018.00086
田中剛平（東京大学・工学系研） Tanaka, G, Dominguez-Huttinger, E., Christodoulides, P., Aihara, K., and Tanaka R. J. Bifurcation analysis of a mathematical model of atopic dermatitis to determine patient-specific effects of treatments on dynamic phenotypes. *Journal of Theoretical Biology* 448, 66-79 (2018). 査読有
難波大輔（東京医科歯科大学・難治研）難波大輔、*松崎恭一：重症下肢虚血における表皮角化幹細胞のクローナル・コンバージョンに関する研究への取り組み形成外科、Vol. 60, 1264-1274 (2017). （査読有）
岩楯好昭（山口大学・創成科学研究科） Okimura, C., Sakumura, Y., Shimabukuro, K. and Iwadate, Y. Sensing of substratum rigidity and directional migration by fast-crawling cells. *Phys. Rev. E* 97, 052401. (2018) 査読有
池ノ内順一（九州大学・理学系） Matsuzawa K,Himoto T,Mochizuki Y, Ikenouchi J. α-Catenin Controls the Anisotropy of Force Distribution at Cell-Cell Junctions during Collective Cell Migration. *Cell Rep.* 23(12):3447-3456. (2018)
池ノ内順一（九州大学・理学系） Tsuchiya M, Hara Y, Okuda M, Itoh K, Nishioka R, Shiomi A, Nagao K, Mori M, Mori Y, Ikenouchi J, Suzuki R, Tanaka M, Ohwada T, Aoki J, Kanagawa M, Toda T, Nagata Y, Matsuda R, Takayama Y, Tominaga M, Umeda M. Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation. Nat Commun. 9(1):2049. (2018)
池ノ内順一（九州大学・理学系） Adherens junctions influence tight junction formation via changes in membrane lipid composition. Shigetomi K, Ono Y, Inai T, Ikenouchi J. *J Cell Biol.* 217(7):2373-2381. (2018)
池ノ内順一（九州大学・理学系） Regulation of the epithelial barrier by post-translational modifications of tight junction membrane proteins. Shigetomi K, Ikenouchi J. J Biochem. 163(4):265-272. (2018)
岩本一成（理研） Magi, S., Iwamoto, K., Yumoto, N., Hiroshima, M., Nagashima, T., Ohki, R., Garcia-Munoz, A., Volinsky, N., Kriegsheim, VA., Sako, Y., Takahashi, K., Kimura, S., Kholodenko BN., Okada-Hatakeyama, M., Transcriptionally inducible Pleckstrin homology-like domain, family A, member 1, attenuates ErbB receptor activity by inhibiting receptor oligomerization, *JBC* 293(6), 2206–2218 (2018). 査読有
渡部昌（北海道大学・医学系研） Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Watanabe, M., and Hatakeyama, S.: Anti-Sez6l2 antibody, detected in a patient with immune-mediated cerebellar ataxia, inhibits complex formation of GluR1 and Sez6l2. J. Neurol.*, 265(4), 962-965(2018).
渡部昌（北海道大学・医学系研） Yabe, I., Yaguchi, H., Kato, Y., Miki, Y., Takahashi, H., Tanikawa, S., Shirai, S., Takahashi, I., Kimura, M., Hama, Y., Matsushima, M., Fujioka, S., Kano, T., Watanabe, M., Nakagawa, S., Kunieda, Y., Ikeda, Y., Hasegawa, M., Nishihara, H., Ohtsuka, T., Tanaka, S., Tsuboi, Y., Hatakeyama, S., Wakabayashi, K. and Sasaki, H. Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome. Sci. Rep.*, 8, 819(2018).
堀雄一郎（大阪大学・工学系研） Hori, Y., Otomura, N., Nishida, A., Nishiura, M., Umeno, M., Suetake, I., *Kikuchi, K. Synthetic-molecule/protein hybrid probe with fluorogenic switch for live-cell imaging of DNA methylation. J. Am. Chem. Soc. 140, 1686-1690 (2018) 査読有
末次志郎（奈良先端科技大・バイオ研） Nishimura, T., Morone, N. Suetsugu, S. Membrane re-modelling by BAR domain superfamily proteins via molecular and non-molecular factors. *Biochem Soc Trans* 46, 379-389 (2018) 査読有
末次志郎（奈良先端科技大・バイオ研）西村珠子、末次志郎：BARドメインタンパク質と細胞骨格による細胞膜の構造構築　　生体の科学　69（3）：1─5，2018
末次志郎（奈良先端科技大・バイオ研）北又学、木田和輝、末次志郎　：生体膜のリポクオリティとタンパク質ドメインによる認識　実験医学増刊号『脂質が支えるバイオロジー』羊土社 2018
小柳光正（大阪市立大学・理学系） Gerrard, E., Mutt, E., Nagata, T., Koyanagi, M., Flock, T., Lesca, E., Schertler, G., Terakita, A., Deupi, X., and Lucas, R. Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish. Proc. Natl. Acad. Sci. USA* 115(24):6201-6206 (2018). 査読有
小柳光正（大阪市立大学・理学系） Nagata, T., Koyanagi, M., Lucas, R., and Terakita, A. An all- trans -retinal-binding opsin peropsin as a potential dark-active and light-inactivated G protein-coupled receptor. Scientific Reports* 8(1), 3535 (2018). 査読有
佐甲靖志（国立研究開発法人理化学研究所） Maeda, R., Hiroshima, M., Yamashita, T., Wada, A., Sako, Y., Shichida, Y. and Imamoto, Y. Shift in conformational equilibrium induces constitutive activity of G-Protein coupled receptor, rhodopsin. J. Phys. Chem. B.* in press. 査読有
佐甲靖志（国立研究開発法人理化学研究所） Magi, S., Iwamoto, K., Yumono, N., Hiroshima, M., Nagashima, T., Ohki, R., Garcia-Munoz, A., Volinsky, N., Von Kriegsheim, A., Sako, Y., Takahashi, K., Kimura, S., Kholodenko, B. N. and Okada-Hatakeyama, M. Transcriptionally inducible Pleckstrin homology-like domain family A member 1 attenuates ErbB receptor activity by inhibiting receptor oligomerization. J. Biol. Chem.* 293, 2206-2218 (2018). 査読有
佐甲靖志（国立研究開発法人理化学研究所） Maeda, R., Sato, T., Okamoto, K., Yanagawa, M. and Sako, Y. Lipid-protein interplay in dimerization of the juxtamembrane domains of epidermal growth factor receptor. Biophys. J.* 114, 893-903 (2018). 査読有
佐甲靖志（国立研究開発法人理化学研究所） Hiroshima, M., Pack, C.-g., Kaizu, K., Takahashi, K., Ueda, M. and Sako, Y. Transient acceleration of epidermal growth factor receptor dynamics produces higher-order signaling clusters. J. Mol. Biol.* 430, 1386-1401 (2018). 査読有
佐甲靖志（国立研究開発法人理化学研究所） Shindo, Y., Kondo, Y. and Sako, Y. Inferring a nonlinear biochemical network model from a heterogeneous single-cell time course data. Sci. Rep.* 8. 6790 (2018). 査読有
大戸梅治（東京大学・薬学研） Sakurai, S., Shimizu, T., & Ohto, U. "The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription." *J. Biol. Chem.* 292, 17609-17616 (2017)
大戸梅治（東京大学・薬学研） Okamoto, N., Mizote, K., Honda, H., Saeki, A., Watanabe, Y., Yamaguchi-Miyamoto, T., Fukui, R., Tanimura, N., Motoi, Y., Akashi-Takamura, S., Kato, T., Fujishita, S., Kimura, T., Ohto, U., Shimizu, T., Hirokawa, T., Miyake, K., Fukase, K., Fujimoto, Y., Nagai, Y., Takatsu, K. "Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex." J. Biol. Chem. 292, 15378-15394 (2017)
大戸梅治（東京大学・薬学研） Zhang, Z., Ohto, U., & Shimizu, T. "Towards a structural understanding of nucleic acid-sensing Toll-like receptors in the innate immune system." FEBS letters.* 591, 3167-3181 (2017)
大戸梅治（東京大学・薬学研） Ohto, U. "Conservation and Divergence of Ligand Recognition and Signal Transduction Mechanisms in Toll-Like Receptors." Chem. Pharm. Bull.* 65, 697-705 (2017)
大戸梅治（東京大学・薬学研） Murakami, K., Nakano, K., Shimizu, T., & Ohto, U. "The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family." *Acta Crystallogr F Struct Biol Commun.* 73, 347-355. (2017)
五島剛太（名古屋大学・理学系） Kosetsu K, Murata T, Yamada M, Nishina M, Boruc J, Hasebe M, Van Damme D, Goshima G. Cytoplasmic MTOCs control spindle orientation for asymmetric cell division in plants. *Proc Natl Acad Sci U S A.* 114(42), E8847-E8854 (2017). 査読有
五島剛太（名古屋大学・理学系） Tungadi EA, Ito A, Kiyomitsu T, Goshima G. Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2. J. Cell Sci.* 130, 3676-3684 (2017). 査読有
五島剛太（名古屋大学・理学系） Beaven R, Bastos RN, Spanos C, Romé P, Cullen CF, Rappsilber J, Giet R, Goshima G, Ohkura H. 14-3-3 regulation of Ncd reveals a new mechanism for targeting proteins to the spindle in oocytes. J. Cell Biol.* 216(10), 3029 (2017). 査読有
五島剛太（名古屋大学・理学系） Yamada M, Tanaka-Takiguchi Y, Hayashi M, Nishina M, Goshima G. Multiple kinesin-14 family members drive microtubule minus-end-directed transport in plant cells. J. Cell Biol.* 216(6), 1705-1714 (2017). 査読有
五島剛太（名古屋大学・理学系） de Keijzer J, Kieft H, Ketelaar T, Goshima G, Janson ME. Shortening of microtubule overlap regions defines membrane delivery sites during plant cytokinesis. Curr Biol.* pii: S0960-9822(16)31524-X (2017). 査読有
岡田雅人（大阪大学・微生物病研究所） Yonehara R, Nada S, Nakai T, Nakai M, Kitamura A, Ogawa A, Nakatsumi H, Nakayama KI, Li S, Standley DM, Yamashita E, Nakagawa A, and Okada M. Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun.* 8, 1625 (2017) 査読有
岡田雅人（大阪大学・微生物病研究所） Hosokawa T, Kimura T, Nada S, Okuno T, Ito D, Kang S, Nojima S, Yamashita K, Nakatani T, Hayama Y, Kato Y, Kinehara Y, Nishide M, Mikami N, Koyama S, Takamatsu H, Okuzaki D, Ohkura N, Sakaguchi S, Okada M, Kumanogoh A. Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function. *J Immunol.* 199, 2008-2019 (2017) 査読有
齊藤達哉（徳島大学・先端酵素学研究所） Takahama M, Fukuda M, Ohbayashi N, Kozaki T, Misawa T, Okamoto T, Matsuura Y, Akira S, Saitoh T. The RAB2B-GARIL5 complex promotes cytosolic DNA-induced innate immune responses. Cell Rep*. 20, 2944-2954(2017). 査読有
齊藤達哉（徳島大学・先端酵素学研究所） Sasai M, Sakaguchi N, Ma JS, Nakamura S, Kawabata T, Bando H, Lee Y, Saitoh T, Akira S, Iwasaki A, Standley DM, Yoshimori T, Yamamoto M. Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense. Nat Immunol*. 18, 899-910(2017). 査読有
松本雅記（九州大学・生体研） Nakatsumi, H., Matsumoto, M., and Nakayama, K.I. Noncanonical pathway for regulation of CCL2 expression by an mTORC1-FOXK1 axis promotes recruitment of tumor-associated macrophages. Cell Rep.* 21, 2471-2486 (2017). 査読あり
松本雅記（九州大学・生体研） Robotic crowd biology with Maholo LabDroids. Yachie, N. Robotic Biology consortium (include Matsumoto, M and Nakayama K.I.), and Natsume, T. Nature Biotechnol.* 35, 310-312 (2017) 査読あり
松本雅記（九州大学・生体研） Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, K.I., Watanabe, M., Hatakeyama, S. Sez6l2 regulates phosphorylation of ADD and neuritogenesis. Biochem Biophys Res Commun.* 494, 234-241 (2017) 査読あり
松本雅記（九州大学・生体研） Kita, K., Shiota, M., Tanaka, M., Otsuka, A., Matsumoto, M., Kato, M., Tamada, S., Iwao, H., Miura, K., Nakatani, T., Tomita, S. Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells. Cancer Sci.* 108, 1820-1827 (2017) 査読あり
松本雅記（九州大学・生体研） Cui, L., Nakano, K., Obchoei, S., Setoguchi, K., Matsumoto, M., Yamamoto, T., Obika, S., Shimada K., Hiraoka, N. Small nucleolar noncoding RNA SNORA23, up-regulated in human pancreatic ductal adenocarcinoma, regulates expression of spectrin repeat-containing nuclear envelope 2 to promote growth and metastasis of xenograft tumors in mice. Gastroenterology*. 153, 292-306 (2017) 査読あり
松本雅記（九州大学・生体研） Matsumoto, M., Matsuzaki, F., Oshikawa, K., Goshima, N., Mori, M., Kawamura Y., Ogawa K., Fukuda, E., Nakatsumi, H., Natsume, T., Fukui, K, Horimoto, K., Nagashima, T., Funayama, R., Nakayama, K., *Nakayama, K.I. A large-scale targeted proteomics assay resource based on an in vitro human proteome. Nature Methods 14, 251-258 (2017) 査読あり
松本雅記（九州大学・生体研） Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A, Nakayama, K.I., Clohessy, J.G., Pandolfi, P.P. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. Nature* 541, 228-232 (2017) 査読あり
松本雅記（九州大学・生体研） Okuda, S., Watanabe, Y., Moriya, Y., Kawano, S., Yamamoto, T., Matsumoto, M., Takami, T., Kobayashi, D., Araki, N., Yoshizawa, A.C., Tabata, T., Sugiyama, N., Goto., S, Ishihama, Y. jPOSTrepo: an international standard data repository for proteomes. Nucleic Acids Res.* 45, D1107-D1111 (2017) 査読あり
松本雅記（九州大学・生体研） Kayama, K., Watanabe, S., Takafuji, T., Tsuji, T., Hironaka, K., Matsumoto, M., Nakayama, K.I., Enari, M., Kohno, T., Shiraishi, K., Kiyono, T., Yoshida, K., Sugimoto, N., Fujita, M. GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis. *EMBO Rep.* 18, 123-137 (2017) 査読あり
橋本博（静岡県立大学・薬学部） Hara, K., Taharazako, S., Ikeda, M., Fujita, F., Mikami, Y., Kikuchi, S., Hishiki, A., Yokoyama, H., Ishikawa, Y., Kanno, S., Tanaka, K. and Hashimoto, H. Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment maintaining phosphoprotein (CAMP). J. Biol. Chem.* 292, 17658-17667 (2017). 査読有
橋本博（静岡県立大学・薬学部） Konishi, H., Matsubara, M., Mori, K., Tokiwa, T., Arulmozhiraja, S., Yamamoto, Y., Ishikawa, Y., Hashimoto, H., Shigeta, Y., Tokiwa, T. and Manabe, K. Mechanistic Insight into Weak-Base-Catalyzed Generation of Carbon Monoxide from Phenyl Formate and Its Application to Catalytic Carbonylation at Room Temperature without Use of External Carbon Monoxide Gas. Adv. Syn. Cat.* 359, 3592-3601 (2017). 査読有
橋本博（静岡県立大学・薬学部） Oda,T., Hirabayashi, H., Shikauchi, G., Takamura, R., Hiraga, K., Minami, H., Hashimoto, H., Yamamoto, M., Wakabayashi, K., Shimizu, T. and Sato, M. Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1. J. Biol. Chem.* 292, 15445-15455 (2017). 査読有
高橋明格（沖縄科学技術大学院大学） Li, X., Morita, M., Kikuguchi, C., Takahashi, A., Suzuki, T., Yamamoto, T. (2017). Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy. FEBS Lett. 591, 358-368. 査読有
中村直俊（京都大学） Akiyama K, Nakamura N, Itatani K, Naito Y, Kinoshita M, Shimizu M, Hamaoka S, Kato H, Yasumoto H, Nakajima Y, Mizobe T, Numata S, Yaku H, Sawa T. Flow-dynamics assessment of mitral-valve surgery by intraoperative vector flow mapping. *Interact Cardiovasc Thorac Surg* 24, 869-875 (2017). 査読有
中村直俊（京都大学） Akiyama K, Maeda S, Matsuyama T, Kainuma A, Ishii M, Naito Y, Kinoshita M, Hamaoka S, Kato H, Nakajima Y, Nakamura N, Itatani K, Sawa T. Vector flow mapping analysis of left ventricular energetic performance in healthy adult volunteers. *BMC Cardiovasc Disord* 17, 21 (2017). 査読有
末次志郎（奈良先端科技大・バイオ研） Tachikawa M, Morone N, Senju Y, Sugiura T, Hanawa-Suetsugu K, Mochizuki A, Suetsugu S. Measurement of caveolin-1 densities in the cell membrane for quantification of caveolar deformation after exposure to hypotonic membrane tension. *Sci Rep* 7, 7794 (2017) 査読有
末次志郎（奈良先端科技大・バイオ研） Takemura K, Hanawa-Suetsugu K, Suetsugu S, Kitao A. Salt Bridge Formation between the I-BAR Domain and Lipids Increases Lipid Density and Membrane Curvature. *Sci Rep*7, 6808 (2017) 査読有
末次志郎（奈良先端科技大・バイオ研） Dumont V, Tolvanen TA, Kuusela S, Wang H, Nyman TA, Lindfors S, Tienari J, Nisen H, Suetsugu S, Plomann M, Kawachi H, Lehtonen S. PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease. *FASEB J*. 31, 3978-3990 (2017) 査読有
池ノ内順一（九州大学・理学系） Kinoshita M, Ano H, Murata M, Shigetomi K, Ikenouchi J, Matsumori N. Emphatic visualization of sphingomyelin-rich domains by inter-lipid FRET imaging using fluorescent sphingomyelins. *Sci Rep.* 7(1):16801 (2017)
渡部昌（北海道大学・医学系研） Watanabe, M. and Hatakeyama, S.: TRIM proteins and diseases. J. Biochem.*, 161, 135-144(2017).
渡部昌（北海道大学・医学系研） Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, KI., Watanabe, M. and Hatakeyama, S.: Sez6l2 regulates phosphorylation of ADD and neuritogenesis. Biochem. Biophys. Res. Commun.*, 494, 234-241(2017).
堀雄一郎（大阪大学・工学系研） ◎Hori, Y., Hirayama, S., Kikuchi, K. Development of cyanine probes with dinitrobenzene quencher for rapid fluorogenic protein labelling. *Philos. Trans. A Math. Phys. Eng. Sci.* 375. pii: 20170018 (2017) 査読有
小柳光正（大阪市立大学・理学系） Matsuo, R., Takatori, Y., Hamada, S., Koyanagi, M., and Matsuo, Y. Expression and light-dependent translocation of β-arrestin in the visual system of the terrestrial slug Limax valentianus. J Exp Biol.*220(Pt 18):3301-3314 (2017). 査読有
佐甲靖志（国立研究開発法人理化学研究所） Sumi, M., Makino, A., Inaba, T., Sako, Y., Fujimori, F., Greimel, P. and Kobayashi, T. Photoswitchable phospholipid FRET acceptor: Detergent free intermembrane transfer assay of fluorescent lipid analogs. Sci. Rep.* 7, 2900 (2017). 査読有
佐甲靖志（国立研究開発法人理化学研究所） Yoshizawa, R., Umeki, N., Yanagawa, M., Murata, M. and Sako, Y. Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction to Ras to Ral. *Biophys. Physicobiol.* 14, 75-84 (2017). 査読有
佐甲靖志（国立研究開発法人理化学研究所） Nakamura, Y.,Umeki, N., Abe M. and Sako, Y. Mutation-specific mechanisms of hyperactivation of Noonan syndrome SOS molecules detected with single-molecule imaging in living cells. Sci. Rep.* 7 (2017). 査読有
2018.4.19	岩楯好昭（山口大学・創成科学研究科） Okimura, C., Sakumura, Y., Shimabukuro, K. and Iwadate, Y. Sensing of substratum rigidity and directional migration by fast-crawling cells *Physical Review E* 97: 052401 (2018). doi:10.1103/PhysRevE.97.052401 [URL]
2018.4.19	岡田雅人（大阪大学・微生物病研究所） Yonehara R, Nada S, Nakai T, Nakai M, Kitamura A, Ogawa A, Nakatsumi H, Nakayama KI, Li S, Standley DM, Yamashita E, Nakagawa A, Okada M. Structuralbasis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun. 2017 Nov 20;8(1):1625. doi: 10.1038/s41467-017-01762-3. [PubMed]
2018.4.19	末次志郎（奈良先端科技大・バイオ研） Takemura K, Hanawa-Suetsugu K, Suetsugu S, Kitao A. Salt Bridge Formation between the I-BAR Domain and Lipids Increases Lipid Density and Membrane Curvature. Sci Rep. 2017 Jul 28;7(1):6808. doi: 10.1038/s41598-017-06334-5. [PubMed]
2018.4.19	末次志郎（奈良先端科技大・バイオ研） Tachikawa M, Morone N, Senju Y, Sugiura T, Hanawa-Suetsugu K, Mochizuki A, Suetsugu S. Measurement of caveolin-1 densities in the cell membrane for quantification of caveolar deformation after exposure to hypotonic membrane tension. Sci Rep. 2017 Aug 10;7(1):7794. doi: 10.1038/s41598-017-08259-5. [PubMed]
2017.11.15	橋本博（静岡県立大学薬学部） Hara K, Taharazako S, Ikeda M, Fujita H, Mikami Y, Kikuchi S, Hishiki A, Yokoyama H, Ishikawa Y, Kanno SI, Tanaka K, Hashimoto H. Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment maintaining phosphoprotein (CAMP). J Biol Chem (2017) 292, 17658. [PubMed]
2017.8.22	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Reiya Taniguchi, Asuka Inoue, Misa Sayama, Akiharu Uwamizu, Keitaro Yamashita, Kunio Hirata, Masahito Yoshida, Yoshiki Tanaka, Hideaki E. Kato, Yoshiko Nakada-Nakura, Yuko Otani, Tomohiro Nishizawa, Takayuki Doi, Tomohiko Ohwada, Ryuichiro Ishitani, Junken Aoki & Osamu Nureki Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA₆. Nature 548, 356-360 (17 August 2017) doi:10.1038/nature23448 [PubMed] http://www.nature.com/nature/journal/v548/n7667/full/nature23448.html
2017.8.14	仁科博史（東京医科歯科大学・難治疾患研究所） Tokiwa Yamasaki, Norie Deki-Arima, Asahito Kaneko, Norio Miyamura, Mamiko Iwatsuki, Masato Matsuoka, Noriko Fujimori-Tonou, Yoshimi Okamoto-Uchida, Jun Hirayama, Jamey D. Marth, Yuji Yamanashi, Hiroshi Kawasaki, Koji Yamanaka, Josef M. Penninger, Shigenobu Shibata and Hiroshi Nishina (2017) Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Scientific Reports 7, 7348. [PubMed]
2017.6.23	鈴木　貴（大阪大学大学院基礎工学研究科） S. Kawasaki, D. Minerva, K. Itano, T. Suzuki, Finding solvable units of variables in nonlinear ODEs of ECM degradation pathway network, Comp. Math. Mech. Machine [PubMed] https://doi.org/10.1155/2017/5924270
2017.5.16	石谷隆一郎（東京大学大学院理学系研究科・生物科学専攻） Kato K, Omura H, Ishitani R, Nureki O. Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA. Annu Rev Biochem. 2017 Apr 7. doi: 10.1146/annurev-biochem-061516-044813. [PubMed]
2017.2.8	尾山大明、秦裕子（東京大・医科研・疾患プロテオミクスラボラトリー） Hashimoto T, Horikawa DD, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T, Enomoto A, Kondo K, Tanaka S, Hara Y, Koshikawa S, Sagara H, Miura T, Yokobori S, Miyagawa K, Suzuki Y, Kubo T, Oyama M, Kohara Y, Fujiyama A, Arakawa K, Katayama T, Toyoda A, and Kunieda T. Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. *Nat. Commun.* 7: 12808 (2016) [PubMed]
2017.2.8	尾山大明、秦裕子（東京大・医科研・疾患プロテオミクスラボラトリー）井上純一郎（東京大・医科研・分子発癌分野） Narushima Y, Kozuka-Hata H, Tsumoto K, Inoue J, and Oyama M. Quantitative phosphoproteomics-based molecular network description for high-resolution kinase-substrate interactome analysis. *Bioinformatics* 32: 2083-2088 (2016) [PubMed]
2017.2.8	尾山大明、秦裕子（東京大・医科研・疾患プロテオミクスラボラトリー） Hirano A, Nakagawa T, Yoshitane H, Oyama M, Kozuka-Hata H, Lanjakornsiripan D, and Fukada Y. USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock. *PLoS One* 11: e0154263 (2016) [PubMed]
2017.2.8	尾山大明、秦裕子（東京大・医科研・疾患プロテオミクスラボラトリー） Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, and Kiyono H. Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody. *Regul. Toxicol. Pharmacol.* 76: 128-136 (2016) [PubMed]
2017.2.8	尾山大明、秦裕子（東京大・医科研・疾患プロテオミクスラボラトリー） Nishimura A, Yamamoto K, Oyama M, Kozuka-Hata H, Saito H, and Tatebayashi K. Scaffold Protein Ahk1, Which Associates with Hkr1, Sho1, Ste11, and Pbs2, Inhibits Cross Talk Signaling from the Hkr1 Osmosensor to the Kss1 Mitogen-Activated Protein Kinase. *Mol. Cell. Biol.* 36: 1109-1123 (2016) [PubMed]
2017.2.8	尾山大明、秦裕子（東京大・医科研・疾患プロテオミクスラボラトリー） Taniue K, Kurimoto A, Sugimasa H, Nasu E, Takeda Y, Iwasaki K, Nagashima T, Okada-Hatakeyama M, Oyama M, Kozuka-Hata H, Hiyoshi M, Kitayama J, Negishi L, Kawasaki Y, and Akiyama T. Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1. *Proc. Natl. Acad. Sci. USA* 113: 1273-1278 (2016) [PubMed]
2017.2.8	尾山大明、秦裕子（東京大・医科研・疾患プロテオミクスラボラトリー） Sato Y, Kato A, Maruzuru Y, Oyama M, Kozuka-Hata H, Arii J, and Kawaguchi Y. Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication. *J. Virol.* 90: 3173-3186 (2016)[PubMed]
2017.2.8	尾山大明、秦裕子（東京大・医科研・疾患プロテオミクスラボラトリー）井上純一郎（東京大・医科研・分子発癌分野） Narushima Y, Kozuka-Hata H, Koyama-Nasu R, Tsumoto K, Inoue J, Akiyama T, and Oyama M. Integrative Network Analysis Combined with Quantitative Phosphoproteomics Reveals TGFBR2 as a Novel Regulator of Glioblastoma Stem Cell Properties. *Mol. Cell. Proteomics* 15: 1017-1031 (2016)[PubMed]
2017.2.8	尾山大明、秦裕子（東京大・医科研・疾患プロテオミクスラボラトリー） Sato Y, Kato A, Arii J, Koyanagi N, Kozuka-Hata H, Oyama M, and Kawaguchi Y. Ubiquitin-specific protease 9X in host cells interacts with herpes simplex virus 1 ICP0. *J. Vet. Med. Sci.* 78: 405-410 (2016) [PubMed]
2017.2.7	徳永文稔（大阪市大・院医・分子病態学） Yamamotoya T, Nakatsu T, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, and Sakoda H. Reduced SHARPIN and LUBAC formation may contribute to CCl4- or acetaminophen-induced liver cirrhosis in mice. *Int. J. Mol. Sci.*18, E326, (2017) [PubMed].
2017.2.6	井上純一郎（東京大・医科研・分子発癌分野） Akiyama, N., Takizawa, N., Miyauchi, M., Yanai, H., Tateishi, R., Shinzawa, M., Yoshinaga, R., Kurihara, M., Demizu, Y., Yasuda, H., Yagi, S., Wu, G., Matsumoto, M., Sakamoto, R., Yoshida, N., Penninger, J.M., Kobayashi, Y., Inoue, J. and Akiyama, T.* Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. J. Exp. Med. 213(8):1441-58. doi: 10.1084/jem.20151780. (2016). [PubMed]
2017.2.6	井上純一郎（東京大・医科研・分子発癌分野） Kawasaki, M., Kawasaki, K., Oommen, S., Blackburn, J., Watanabe, M., Nagai, T., Kitamura, A., Maeda, T., Liu, B., Schmidt-Ullrich, R., Akiyama, T., Inoue, J., Hammond, N.L., Sharpe, P.T. and Ohazama, A.* Regional regulation of filiform tongue papillae development by Ikka /Irf6. *Dev. Dyn.* doi: 10.1002/dvdy.24427 (2016). [PubMed]
2017.2.6	井上純一郎（東京大・医科研・分子発癌分野） Yamamoto, M., Mastsuyama, S., Li, X., Takeda, M., Kawaguchi, Y., Inoue, J.* and Matsuda, Z.* Identification of nafamostat as a potent inhibitor of Middle East respiratory syndrome (MERS) corona virus S-mediated membrane fusion using the split protein-based cell-cell fusion assay. *Antimicrob. Agents Chemother.* 60(11):6532-6539. doi: 10.1128/AAC.01043-16 (2016). [PubMed]
2017.2.6	井上純一郎（東京大・医科研・分子発癌分野） Yu, J., Yun, H., Shin, B., Kim, Y., Park, E.S., Choi, S., Yu, J., Amarasekara, D.S., Kim, S., Inoue, J., Walsh, M.C., Choi, Y., Takami, M. and Rho, J.* Interaction of tumor necrosis factor receptor-associated factor 6 (TRAF6) and Vav3 in the receptor activator of nuclear factor kB (RANK) signaling complex enhances osteoclastogenesis. *J. Biol. Chem.* (2016) 291(39):20643-60. doi: 10.1074/jbc.M116.728303. [PubMed]
2017.2.6	井上純一郎（東京大・医科研・分子発癌分野） Varney, M., Choi, K., Bolanos, L., Christie, S., Fang, J., Grimes, L., Maciejewski, J., Inoue, J. and Starczynowski D. Epistasis between TIFAB and miR-146a, neighboring genes in del(5q) MDS. *Leukemia* (2017) 31, 491–495; doi:10.1038/leu.2016.276 [PubMed]
2017.2.6	井上純一郎（東京大・医科研・分子発癌分野）徳永文稔（大阪市大・院医・分子病態学） Shibata, Y., Tokunaga, F., Goto, E., Komatsu, G., Gohda, J., Saeki, Y., Tanaka, K., Takahashi, H., Sawasaki, T., Inoue, S., Oshiumi, H., Seya, T., Nakano, H., Tanaka, Y., Iwai, K. and Inoue, J. HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. *PLoS Pathogens* 13(1):e1006162. doi: 10.1371/journal.ppat.1006162 (2017). [PubMed]
2017.2.6	徳永文稔（大阪市大・院医・分子病態学） Hattori M, Shimuzu A, Oikawa D, Kamei K, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Tokunaga F, Ishikawa O. ER stress in the pathogenesis of pretibial dystrophic epidermolysis bullosa. Br. J. Dermatol. (in press)[PubMed]
2017.2.6	徳永文稔（大阪市大・院医・分子病態学） Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, and Nureki O. Structural and functional analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide. Sci. Rep. 6, 34756 (2016) [PubMed].
2017.2.6	徳永文稔（大阪市大・院医・分子病態学） Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, and Tokunaga F. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat. Commun. 7, 12547 (2016) [PubMed].
2017.2.6	徳永文稔（大阪市大・院医・分子病態学） Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsnomiya A, Watanabe T, and Yamaoka S. A20 targets caspase-8 and FADD to protect HTLV-I infected cells. *Leukemia*, 30, 716-727 (2016) [PubMed].
2017.2.3	武川睦寛（東京大・医科研・分子シグナル制御分野） Arimoto-Matsuzaki K, Saito H and Takekawa M. TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis. *Nature Communications* 7: 10252 doi:10.1038/ncomms10252 (2016) [PubMed]
2017.2.3	武川睦寛（東京大・医科研・分子シグナル制御分野） Hijiya N, Tsukamoto Y, Nakada C, Tung NL, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, and Moriyama M. Genomic loss of DUSP4 contributes to the progression of intraepitherial neoplasm of pancreas to invasive carcinoma. *Cancer Research* 76: 2612-2625 (2016) [PubMed]
2017.2.3	武川睦寛（東京大・医科研・分子シグナル制御分野） Kinoshita E, Kinoshita-Kikuta E, Kubota Y, Takekawa M and Koike T. A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1. *Proteomics* 16:1825-1836 (2016) [PubMed]
2017.2.3	武川睦寛（東京大・医科研・分子シグナル制御分野） Kubota Y and Takekawa M. Detection and functional analysis of SUMO-modified MEK. *Methods in Molecular Biology* 1487, 99-111 (2016) [PubMed]
2017.2.3	武川睦寛（東京大・医科研・分子シグナル制御分野）武川睦寛 MAPキナーゼ情報伝達経路の活性制御機構と疾患発症機構の解明生物物理化学 60巻 7-10 (2016). [URL]

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