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研究成果

2018.8.29 井上純一郎(東京大学医科学研究所・分子発癌分野)
Gohda J, Suzuki K, Liu K, Xie X, Takeuchi H, Inoue J, Kawaguchi Y and *Ishida T. BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1. Sci. Rep. 8:3521 (2018).
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Maruyama T, Imai S, Kusakizako T, Hattori M, Ishitani R, Nureki O, Ito K, Maturana AD, Shimada I and Osawa M. Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR. eLife 7, e31596 (2018)
武川睦寛(東京大学医科学研究所・分子シグナル制御分野)
◎▲Iijima M, Kubota Y, Sawa R, Kubota Y, Hatano M, Arashi M, Kawada M, Momose I, *Takekawa M and *Shibasaki M. A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. J Antibiot, 71, 135–138 (2018)
武川睦寛(東京大学医科学研究所・分子シグナル制御分野)
Ichimanda M, Hijiya N, Tsukamoto Y, Uchida T, Nakada, C, Akagi T, Etoh T, Iha H, Inomata M, Takekawa M and *Moriyama M. Downregulation of DUSP4 enhances cell proliferation and invasiveness in colorectal carcinomas. Cancer Sci. 109, 250-258 (2018).
上野 匡(東京大学大学院薬学系研究科・薬品代謝化学教室)
◎▲Taguchi R., Terai T., Ueno T., Komatsu T., Hanaoka K., *Urano Y. A Protein-Coupled Fluorescent Probe For Organelle-Specific Imaging of Na+. Sens Act B Chem 265, 575-581 (2018)
上野 匡(東京大学大学院薬学系研究科・薬品代謝化学教室)
◎▲Kuriki Y, Kamiya M, Kubo H, Komatsu T, Ueno T, Tachibana R, Hayashi K, Hanaoka K, Yamashita S, Ishizawa T, Kokudo N & *Urano Y. Establishment of Molecular Design Strategy to Obtain Activatable Fluorescent Probes for Carboxypep. J Am Chem Soc 140, 1767-1773 (2018)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
◎▲Taniguchi R, Inoue A, Sayama M, Uwamizu A, Yamashita K, Hirata K, Yoshida M, Tanaka Y, Kato E, Nakada Y, Otani Y, Nishizawa T, Ohwada T, Ishitani R, *Aoki J, *Nureki O. Structural insights into ligand recognition by the lysophosphatidic acid R LPA6. Nature 548, 356-360 (2017)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Yamano T, Zetsche B, Ishitani R, Zhang F, Nishimasu H, *Nureki O. Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1. Mol. Cell 67 633-645 (2017)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Yamada M, Watanabe Y, Gootenberg JS, Hirano H, Ran FA, Nakane T, Ishitani R, Zhang F, *Nishimasu H, *Nureki O. Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems. Mol Cell 65, 1109-1121 (2017)
井上純一郎(東京大学医科学研究所・分子発癌分野)
◎▲Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K and *Inoue J. HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. PLoS Pathog 13(1):e1006162 (2017).
武川睦寛(東京大学医科学研究所・分子シグナル制御分野)
◎▲Kubota Y, Fujioka K and *Takekawa M. WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins. PLoS ONE 12: e0180714. doi.org/10.1371/journal.pone.0180714 (2017)
武川睦寛(東京大学医科学研究所・分子シグナル制御分野)
◎▲Kubota Y and *Takekawa M. Detection and functional analysis of SUMO-modified MEK. Methods Mol Biol 1487, 99-111, (2017)
井上純一郎(東京大学医科学研究所・分子発癌分野)
Magilnick N, Reyes EY, Wang WL, Vonderfecht S, Gohda J, Inoue J, *Boldin MP. The miR-146a-Traf6 regulatory axis controls autoimmunity and myelopoiesis, but is dispensable for hematopoietic stem cell homeostasis and tumor suppression. Proc Natl Acad Sci USA 114, 7140-7149 (2017).
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Nishimasu H, Yamano T, Gao L, Zhang F, Ishitani R, *Nureki O. Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf1. Mol. Cell 67, 139-147 (2017)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
◎Miyauchi H, Moriyama S, Kusakizako T, Kumazaki K, Nakane T, Yamashita K, Hirata K, Dohmae N, Nishizawa T, Ito K, Miyaji T, Moriyama Y, *Ishitani R, *Nureki O. Structural basis for xenobiotic extrusion by eukaryotic MATE transporter. Nat Commun. 8, 1633 (2017)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Tomita A, Zhang M, Jin F, Zhuang W, Takeda H, Maruyama T, Osawa M, Hashimoto KI, Kawasaki H, Ito K, Dohmae N, Ishitani R, Shimada I, *Yan Z, *Hattori M, *Nureki O ATP-dependent modulation of MgtE in Mg2+ homeostasis. Nat Commun. 8, 148 (2017)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Kasuya G, Yamaura T, Ma XB, Nakamura R, Takemoto M, Nagumo H, Tanaka E, Dohmae N, Nakane T, Yu Y, Ishitani R, Matsuzaki O, Hattori M, *Nureki O. Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel. Nat Commun. 8, 876 (2017)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Lee Y, Nishizawa T, Takemoto M, Kumazaki K, Yamashita K, Hirata K, Minoda A, Nagatoishi S, Tsumoto K, Ishitani R, Nureki O*. Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity. Nat Plants 3, 825–832 (2017)
井上純一郎(東京大学医科学研究所・分子発癌分野)
Varney M, Choi K, Bolanos L, Christie S, Fang J, Grimes H.L, Maciejewski J, Inoue J and *Starczynowski D. Epistasis between TIFAB and miR-146a, neighboring genes in del(5q) MDS. Leukemia 31, 491–495 (2017).
上野 匡(東京大学大学院薬学系研究科・薬品代謝化学教室)
◎▲Chiba M, Ichikawa Y, Kamiya M, Komatsu T, Ueno T, Hanaoka K, Nagano T, Lange N. and *Urano Y. An Activatable Photosensitizer Targeted to γ-Glutamyltranspeptidase Angew Chem Int Ed 56, 10418-10422 (2017)
上野 匡(東京大学大学院薬学系研究科・薬品代謝化学教室)
◎▲Piao W, Hanaoka K, Fujisawa T, Takeuchi S, Komatsu T, Ueno T, Terai T, Tahara T, Nagano T. and *Urano Y. Development of an Azo-based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy. J Am Chem Soc , 139, 13713–13719 (2017)
上野 匡(東京大学大学院薬学系研究科・薬品代謝化学教室)
◎▲Onagi J, Komatsu T, Ichihashi Y, Kuriki Y, Kamiya M, Terai T, Ueno T, Hanaoka K, Matsuzaki H, Hata K, Watanabe T, Nagano T, and *Urano Y. Discovery of Cell-type-specific and Disease-related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism J Am Chem Soc 139, 3465–3472 (2017)
井上純一郎(東京大学医科学研究所・分子発癌分野)
◎▲Yamamoto M, Sakane K, Tominaga K, Gotoh N, Niwa T, Kikuchi Y, Tada K, Goshima N, Semba K and *Inoue J. Intratumoral bidirectional transitions between epithelial and mesenchymal cells in triple-negative breast cancer. Cancer Sci. 108, 1210-1222 (2017). doi: 10.1111/cas.13246.
徳永文稔(大阪市立大学大学院医学研究科・分子病態学)
▲Goto E and *Tokunaga F. Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP. Biochem. Biophys. Res. Commun. 485, 152-159, (2017).
井上純一郎(東京大学医科学研究所・分子発癌分野)
*Into T, Horie T, Inomata1 M, Gohda J, Inoue J, Murakami Y and Niida S. Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88. Sci. Rep. 7: 1009 (2017).
武川睦寛(東京大学医科学研究所・分子シグナル制御分野)
◎▲Arimoto-Matsuzaki K, Saito H and *Takekawa M. TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis. Nat Commun. 7: 10252 (2016)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Matsumoto N, *Nishimasu H, Sakakibara K, Nishida KM, Hirano T, Ishitani R, Siomi H, *Siomi MC, *Nureki O. Crystal Structure of Silkworm PIWIClade Argonaute Siwi Bound to piRNA. Cell 167, 484-497 (2016)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Yamano T, Nishimasu H, Zetsche B, Hirano H, Slaymaker IM, Li Y, Fedorova I, Nakane T, Makarova KS, Koonin EV, Ishitani R, *Zhang F, *Nureki O. Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA. Cell 165, 949-962 (2016)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Hirano H, Gootenberg JS, Horii T, Abudayyeh OO, Kimura M, Hsu PD, Nakane T, Ishitani R, Hatada I, Zhang F, *Nishimasu H, *Nureki O. Structure and Engineering of Francisella novicida Cas9. Cell 164, 950-961 (2016)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Tsuchiya H, Doki S, Takemoto M, Ikuta T, Higuchi T, Fukui K, Usuda Y, Tabuchi E, Nagatoishi S, Tsumoto K, Nishizawa T, Ito K, Dohmae N, *Ishitani R, *Nureki O. Structural basis for amino acid export by DMT superfamily transporter YddG. Nature 534, 417-420 (2016)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Hirano S, *Nishimasu H, Ishitani R, Nureki O. Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9. Mol Cell 61, 886-894 (2016)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Morita J, Kato K, Nakane T, Kondo Y, Fukuda H, Nishimasu H, *Ishitani R, *Nureki O. Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide. Nat Commun. 7, 12383 (2016)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Kato K, Satouh Y, Nishimasu H, Kurabayashi A, Morita J, Fujihara Y, Oji A, Ishitani R, *Ikawa M, *Nureki O. Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization. Nat Commun. 7, 12198 (2016)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
◎▲Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, *Ito H, *Nureki O, *Tokunaga F. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 7, 12547 (2016)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Kato K, Ikeda H, Miyakawa S, Futakawa S, Nonaka Y, Fujiwara M, Okudaira S, Kano K, Aoki J, Morita J, Ishitani R, Nishimasu H, *Nakamura Y, *Nureki O. Structural basis for specific inhibition of Autotaxin by a DNA aptamer. Nat Struct Mol Biol 23, 395-401 (2016)
井上純一郎(東京大学医科学研究所・分子発癌分野)
Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger J.M, Kobayashi Y, Inoue J and *Akiyama T. Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. J. Exp. Med. 213(8):1441-58. (2016).
徳永文稔(大阪市立大学大学院医学研究科・分子病態学)
Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsnomiya A, Watanabe T and *Yamaoka S. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells. Leukemia 30,716-727, (2016).
上野 匡(東京大学大学院薬学系研究科・薬品代謝化学教室)
Kim AK, DeRose R, Ueno T, Lin B, Komatsu T, Nakamura H and *Inoue T. Toward Total Synthesis of Cell Function: Reconstituting Cell Dynamics with Synthetic Biology. Sci. Signaling, 9, re1 (2016)
武川睦寛(東京大学医科学研究所・分子シグナル制御分野)
◎▲Hijiya N, Tsukamoto Y, Nakada C, Tung NL, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, and *Moriyama M. Genomic loss of DUSP4 contributes to the progression of intraepitherial neoplasm of pancreas to invasive carcinoma. Cancer Res 76: 2612-2625, (2016)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
◎▲Omura H, Oikawa D, Nakane T, Kato M, Ishii R, *Ishitani R, *Tokunaga F, *Nureki O. Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide. Sci. Rep. 6, 34756 (2016)
武川睦寛(東京大学医科学研究所・分子シグナル制御分野)
◎Kinoshita E, Kinoshita-Kikuta E, Kubota Y, Takekawa M and *Koike T. A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1. Proteomics 16: 1825-1836, (2016)
井上純一郎(東京大学医科学研究所・分子発癌分野)
Yu J, Yun H, Shin B, Kim Y, Park E.S, Choi S, Yu J, Amarasekara D.S, Kim S, Inoue J, Walsh M.C, Choi Y, Takami M and *Rho J. Interaction of tumor necrosis factor receptor-associated factor 6 (TRAF6) and Vav3 in the receptor activator of nuclear factor kB (RANK) signaling complex enhances osteoclastogenesis. J. Biol. Chem. 291(39):20643-60. (2016)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Kasuya G, Hiraizumi M, Maturana AD, Kumazaki K, Fujiwara Y, Liu K, Nakada-Nakura Y, Iwata S, Tsukada K, Komori T, Uemura S, Goto Y, Nakane T, Takemoto M, Kato HE, Yamashita K, Wada M, Ito K, Ishitani R, *Hattori M, *Nureki O. Crystal structures of the TRIC trimeric intracellular cation channel orthologues. Cell Res. 26, 1288-1301 (2016)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Kasuya G, Fujiwara Y, Tsukamoto H, Morinaga S, Ryu S, Touhara K, Ishitani R, Furutani Y, *Hattori M, *Nureki O. Structural insights into the nucleotide base specificity of P2X receptors. Sci. Rep. 7, 45208 (2016)
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Kasuya G, Fujiwara Y, Takemoto M, Dohmae N, Nakada-Nakura Y, Ishitani R, *Hattori M, *Nureki O. Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels. Cell Rep. 14, 932-944 (2016)
鈴木 貴(大阪大学大学院基礎工学研究科・システム創成選考)
◎▲*Suzuki T, Pierre M and Yamada Y. Dissipative reaction diffusion systems with quadratic growth. Indiana Univ. Math. J. in press
久保田浩行(九州大学生体防御医学研究所・統合オミクス分野)
◎▲ *Kubota H, Uda S, Matsuzaki F, Yamauchi Y and *Kuroda S. Selective control of the Insulin-AKT pathway by simultaneous processing of blood insulin patterns in vivo. Cell Systems. in press (2018).
鈴木 貴(大阪大学大学院基礎工学研究科・システム創成選考)
*Suzuki T, Dhisa M, Nishiyama K, Koshikawa N and Chaplain M. Study on the tumor-induced angiogenesis using mathematical models. Cancer Science (2018) 15-23, DOI:10.1111/cas.13395(2018)
鈴木 貴(大阪大学大学院基礎工学研究科・システム創成選考)
◎▲*Suzuki T, Kobayashi M and Yamada Y. Lotka-Volterra systems with periodic orbits, Funkcialaj Ekvacioj 61 (2018)
鈴木 貴(大阪大学大学院基礎工学研究科・システム創成選考)
◎▲*Suzuki T and Sasaki T. Asymptotic behaviour of the solution to a virus dynamics model with diffusion. DCDS-B , ABNS 23(2), 525-541, doi:10.3934/dcdsb.2017206 (2018)
久保田浩行(九州大学生体防御医学研究所・統合オミクス分野)
◎▲ Tsucguya T, Fujii M, Matsuda N, Kunida K, Uda S, Kubota H, Konishi K and *Kuroda S. System identification of signaling dependent gene expression with different time-scale data. PLoS Comput. Biol. 13(12): e1005913 (2017).
鈴木 貴(大阪大学大学院基礎工学研究科・システム創成選考)
*Suzuki T, Pierre M and Umakoshi H. Global-in-time behavior of weak solution to reaction diffusion system with inhomogeneous Dirichlet boundary condition. Nonlinear Anal. TMA 159 ,393-407. DOI. 10.1016/j.na.2017.01.013(2017)
鈴木 貴(大阪大学大学院基礎工学研究科・システム創成選考)
*Suzuki T and Espejo E. Reaction enhancement by chemotaxis in a model describing fertitization of corals. Nonlinear Analysis: Real World Applications 35 ,102-131. (2017)
鈴木 貴(大阪大学大学院基礎工学研究科・システム創成選考)
◎▲Kawasaki S, Minerva D, Itano K and *Suzuki T. Finding solvable units of variables in nonlinear ODEs of ECM degradation pathway network. Comp. Math. Mech. Medicine., 1-15, ID5924270. Open https://doi.org/10.1155/2017/5924270 , (2017)
鈴木 貴(大阪大学大学院基礎工学研究科・システム創成選考)
*Suzuki T, Pierre M and Zou R. Asymptotic behavior of renormalized solution to chemical reaction diffusion systems. JMAA , 450 (1), 152-168, DOI. 10.1016/j.jmaa.2017.01.022, (2017)
鈴木 貴(大阪大学大学院基礎工学研究科・システム創成選考)
*Suzuki Y and Kavallaris N.I. A non-local parabolic equation associated with Gierer-Meinhardt system Nonlinearity. NON-101571.R1 (2017)
鈴木 貴(大阪大学大学院基礎工学研究科・システム創成選考)
Gallinato O, Ohta M, Poignard C and *Suzuki T. Free boundary problem for cell protrusion formations. J. Math. Biol. 1-45 (2016)
澤崎達也(愛媛大学 プロテオサイエンスセンター)
◎▲Nemoto K, Kagawa M, Nozawa A, Hasegawa Y, Hayashi M, Imai K, Tomii K and *Sawasaki T. Identification of new abscisic acid receptor agonists using a wheat cell-free based drug screening system. Sci Rep. 2018 Mar 9;8(1):4268. doi: 10.1038/s41598-018-22538-9. (2018)
尾山大明(東京大学医科学研究所・疾患プロテオミクスラボラトリー)
◎▲*Fujita T#, Kozuka-Hata H# (#; equal contribution), Hori Y, Takeuchi J, Kubo T and *Oyama M. Shotgun proteomics deciphered age/division of labor-related functional specification of three honeybee (Apis mellifera L.) exocrine glands. PLoS ONE , 13, e0191344 (2018).
澤崎達也(愛媛大学 プロテオサイエンスセンター)
◎▲Uematsu A, Kido K, Manabe E, Takeda H, Takahashi H, Hayashi M, Imai Y and *Sawasaki, T. DANFIN functions as an inhibitor of transcription factor NF-κB and potentiates the antitumor effect of bortezomib in multiple myeloma. Biochem Biophys Res Commun . 495(3):2289-2295. doi: 10.1016/j.bbrc.2017.12.142. (2018)
尾山大明(東京大学医科学研究所・疾患プロテオミクスラボラトリー)
◎*Inoue D, Fujino T, Sheridan P, Zhang Y.Z, Nagase R, Horikawa S, Li Z, Matsui H, Kanai A, Saika M, Yamaguchi R, Kozuka-Hata H, Kawabata K, Yokoyama A, Goyama S, Inaba T, Imoto S, Miyano S, Xu M, Yang F.C, Oyama M and *Kitamura T. A novel ASXL1–OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies. Leukemia , doi:10.1038/s41375-018-0083-3 (2018).
尾山大明(東京大学医科学研究所・疾患プロテオミクスラボラトリー)
◎Kikuchi K, Kozuka-Hata H, Oyama M, Seiki M and *Koshikawa N. Identification of Proteolytic Cleavage Sites of EphA2 by Membrane Type 1 Matrix Metalloproteinase on the Surface of Cancer Cells. Methods Mol. Biol. , 1731, 29-37 (2018).
澤崎達也(愛媛大学 プロテオサイエンスセンター)
Miura T, Takeo S, Ntege E.H, Otsuki H, Sawasaki T, Ishino T, Takashima E and *Tsuboi T. The malaria parasite RhopH protein complex interacts with erythrocyte calmyrin identified from a comprehensive erythrocyte protein library. Biochem Biophys Res Commun . 500(2):261-267.(2018)
澤崎達也(愛媛大学 プロテオサイエンスセンター)
◎▲Nemoto K, Ramadan A, Arimura G.I, Imai K, Tomii K, Shinozaki, K and *Sawasaki, T. Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation. Nat Commun. 8(1):1004. doi: 10.1038/s41467-017-01005-5. (2017)
尾山大明(東京大学医科学研究所・疾患プロテオミクスラボラトリー)
◎Saitoh S.I, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K and *Miyake K. TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells. Nat. Commun., 8, 1592 (2017).
澤崎達也(愛媛大学 プロテオサイエンスセンター)
◎▲Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K and *Inoue J. HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains. PLoS Pathog. 13, e100162, (2017).
澤崎達也(愛媛大学 プロテオサイエンスセンター)
◎▲Takeda H, Zhou W, Kido K, Suno R, Iwasaki T, Kobayashi T and *Sawasaki, T. CP5 system, for simple and highly efficient protein purification with a C-terminal designed mini tag. PLoS ONE . 12(5):e0178246. doi: 10.1371/journal.pone.0178246. (2017)
尾山大明(東京大学医科学研究所・疾患プロテオミクスラボラトリー)
◎Contu V.R, Hase K, Kozuka-Hata H, Oyama M, Fujiwara Y, Kabuta C, Takahashi M, Hakuno F, Takahashi S.I, Wada K and *Kabuta T. Lysosomal targeting of SIDT2 via multiple YxxΦ motifs is required for SIDT2 function in the process of RNautophagy. J. Cell Sci., 130, 2843-2853 (2017).
尾山大明(東京大学医科学研究所・疾患プロテオミクスラボラトリー)
◎Suzawa M, Noguchi K, Nishi K, Kozuka-Hata H, Oyama M and *Ui-Tei K. Comprehensive Identification of Nuclear and Cytoplasmic TNRC6AAssociating Proteins. J. Mol. Biol., 429, 3319-3333 (2017).
澤崎達也(愛媛大学 プロテオサイエンスセンター)
Sun S, Nakashima K, Ito M, Li Y, Chida T, Takahashi H, Watashi K, Sawasaki T, Wakita T and *Suzuki T. Involvement of PUF60 in Transcriptional and Post-transcriptional Regulation of Hepatitis B Virus Pregenomic RNA Expression. Sci Rep. 7(1):12874. (2017)
澤崎達也(愛媛大学 プロテオサイエンスセンター)
Yonezawa T, Takahashi H, Shikata S, Liu X, Tamura M, Asada S, Fukushima T, Fukuyama T, Tanaka Y, Sawasaki T, Kitamur, T and *Goyama, S. The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1. J Biol Chem. 292(30):12528-12541. (2017)
澤崎達也(愛媛大学 プロテオサイエンスセンター)
Liu S, Hasegawa H, Takemasa E, Suzuki Y, Oka K, Kiyoi T, Takeda H, Ogasawara T, Sawasaki T, Yasukawa M and *Maeyama K. Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models. J Immunol. 199:1584-1595. doi: 10.4049/jimmunol.1700192. (2017)
澤崎達也(愛媛大学 プロテオサイエンスセンター)
Yamamoto T, Taira-Nihira N, Yogosawa S, Aoki K, Takeda H, Sawasaki T and *Yoshida K. Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks. FEBS Lett. 591(6):842-853. doi: 10.1002/1873-3468.12596. (2017)
澤崎達也(愛媛大学 プロテオサイエンスセンター)
Hashimoto Y, Shirakura K, Okada Y, Takeda H, Endo K, Tamura M, Watari A, Sadamura Y, Sawasaki T, Doi T, Yagi K and *Kondoh, M. Claudin-5- binders enhance permeation of solutes across the blood-brain barrier in a mammalian model. J Pharmacol Exp Ther. 363(2):275-283.(2017)
澤崎達也(愛媛大学 プロテオサイエンスセンター)
◎▲Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O and *Tokunaga F. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 7:12547. doi: 10.1038/ncomms12547. (2016)
尾山大明(東京大学医科学研究所・疾患プロテオミクスラボラトリー)
◎Hashimoto T, Horikawa D.D, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T, Enomoto A, Kondo K, Tanaka S, Hara Y, Koshikawa S, Sagara H, Miura T, Yokobori S, Miyagawa K, Suzuki Y, Kubo T, Oyama M, Kohara Y, Fujiyama A, Arakawa K, Katayama T, *Toyoda A and *Kunieda T. Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. Nat Commun., 7, 12808 (2016).􀀃
澤崎達也(愛媛大学 プロテオサイエンスセンター)
Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T and *Yamashita M. Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop. Nat Commun. 7:12596. doi: 10.1038/ncomms12596. (2016)
尾山大明(東京大学医科学研究所・疾患プロテオミクスラボラトリー)
◎▲Narushima Y, Kozuka-Hata .H, Tsumoto K, Inoue J and *Oyama M. Quantitative phosphoproteomics-based molecular network description for high-resolution kinase-substrate interactome analysis. Bioinformatics, 32, 2083-2088 (2016).
澤崎達也(愛媛大学 プロテオサイエンスセンター)
◎▲Yano T, Takeda H, Uematsu A, Yamanaka S, Nomura S, Nemoto K, Iwasaki T, Takahashi H and *Sawasaki T. AGIA Tag System Based on a High Affinity Rabbit Monoclonal Antibody against Human Dopamine Receptor D1 for Protein Analysis. PLoS ONE . 11(6):e0156716. (2016)
尾山大明(東京大学医科学研究所・疾患プロテオミクスラボラトリー)
◎Hirano A, Nakagawa T, Yoshitane H, Oyama M, Kozuka-Hata H, Lanjakornsiripan D and *Fukada Y. USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock. PLoS ONE , 11, e0154263 (2016).
澤崎達也(愛媛大学 プロテオサイエンスセンター)
Takahashi H, Uematsu A, Yamanaka S, Imamura M, Nakajima T, Doi K, Yasuoka S, Takahashi C, Takeda H and *Sawasaki T. Establishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate Proteins. PLoS ONE . 11(6):e0156718. doi: 10.1371/journal.pone.0156718. (2016)
澤崎達也(愛媛大学 プロテオサイエンスセンター)
Santolini M, Sakakibara I, Gauthier M, Ribas F, Takahashi H, Sawasaki T, Mouly V, Concordet J.P, Defossez P.A, Hakim V and *Maire P. MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis. Nucleic Acids Res. 44(18):8621-8640. (2016)
澤崎達也(愛媛大学 プロテオサイエンスセンター)
Ogawa S, Miyamoto K, Nemoto K, Sawasaki T, Yamane H, Nojiri H and *Okada K. OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability. Sci Rep. 7:40175. doi: 10.1038/srep40175. (2016)
澤崎達也(愛媛大学 プロテオサイエンスセンター)
Takagi M, Sakamoto T, Suzuki R, Nemoto K, Obayashi T, Hirakawa T, Matsunaga T.M, Kurihara D, Nariai Y, Urano T, Sawasaki T and *Matsunaga S.􀀃 Plant Aurora kinases interact with and phosphorylate transcription factors. J Plant Res. 129(6):1165-1178. (2016)
澤崎達也(愛媛大学 プロテオサイエンスセンター)
Sakamaki K, Ishii T.M, Sakata T, Takemoto K, Takagi C, Takeuchi A, Morishita R, Takahashi H, Nozawa A, Shinoda H, Chiba K, Sugimoto H, Saito A, Tamate S, Satou Y, Jung S,K, Matsuoka S, Koyamada K, Sawasaki T, Nagai T and *Ueno N. Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage. Biochim Biophys Acta. pii: S0167-4889(16)30215-4. doi: 10.1016/j.bbamcr.2016.08.010. (2016)
仁科 博史(東京医科歯科大学・難治疾患研究所)
Tokiwa Yamasaki, Norie Deki-Arima, Asahito Kaneko, Norio Miyamura, Mamiko Iwatsuki, Masato Matsuoka, Noriko Fujimori-Tonou, Yoshimi Okamoto-Uchida, Jun Hirayama, Jamey D. Marth, Yuji Yamanashi, Hiroshi Kawasaki, Koji Yamanaka, Josef M. Penninger, Shigenobu Shibata and Hiroshi Nishina (2017) Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Scientific Reports 7, 7348.
大戸 梅治 (東京大学・薬学研)
Ohto, U.
, Ishida, H., Shibata, T., Sato, R., Miyake, K., *Shimizu, T.
"Two DNA binding sites on Toll-like receptor 9 function cooperatively in receptor activation"
Immunity 48, 649-658 (2018)
大戸 梅治 (東京大学・薬学研)
*Miyake, K., Shibata, T., Ohto, U., Shimizu, T., Saitoh, S. I., Fukui, R., Murakami, Y. "Mechanisms controlling nucleic acid-sensing Toll-like receptors"
Int Immunol. 30, 43-51 (2018)
大戸 梅治 (東京大学・薬学研)
Zhang, S., Hu, Z., Tanji, H., Jiang, S., Das, N, Li, J., Sakaniwa, K., Jin, J., Bian, Y., Ohto, U., *Shimizu, T., *Yin, H.
"Small-molecule inhibition of TLR8 through stabilization of its resting state"
Nature Chem. Biol. 14, 58-64 (2018)
本田 信治(福井大学・医学部)
Jamieson K, McNaught KJ, Ormsby T, Leggett NA, Honda S, and *Selker EU.
Telomere repeats induce domains of H3K27 methylation in Neurospora
eLife 7, e31216 (2018) . 査読有
五島 剛太 (名古屋大学・理学系)
Leong SY, Yamada M, Yanagisawa N, *Goshima G.  SPIRAL2 stabilises endoplasmic microtubule minus ends in the moss Physcomitrella patens. Cell Struct Funct. 43(1), 53-60 (2018). 査読有
花房 洋(名古屋大学・理学系)
Hisamoto, N., Tsuge, A., Pastuhov, S., Shimizu, T., Hanafusa, H. and *Matsumoto, K. Phosphatidylserine exposure mediated by ABC transporter activates the integrin signaling pathway promoting axon regeneration. Nature Commun. in press査読有
花房 洋(名古屋大学・理学系)
Shimizu, T., Pastuhov, S., Hanafusa, H., *Matsumoto, K. and Hisamoto, N.  The C. elegans BRCA2-ALP/Enigma complex regulates axon regeneration via a Rho GTPase-ROCK-MLC phosphorylation pathway. Cell Reports in press 査読有
藤田 宏明(京都大学・医学系研)
Fujita H, Tokunaga A, Shimizu S, Whiting AL, Aguilar-Alonso F, Takagi K, Walinda E, Sasaki Y, Shimokawa T, Mizushima T, Ohki I, Ariyoshi M, Tochio H, Bernal F, Shirakawa M, and *Iwai K., Cooperative domain formation by homologous motifs in HOIL-1L and SHARPIN plays crucial roles in LUBAC stabilization. Cell reports, 23(4), 1192-1204 (2018) 査読有
岡田 雅人(大阪大学・微生物病研究所)
Tsukamoto T, Kajiwara K, Nada S, *Okada M. Src mediates TGF-β–induced intraocular pressure elevation in glaucoma. J Cell Physiol. in press. (2018)査読有
岡田 雅人(大阪大学・微生物病研究所)
Hayama Y, *Kimura T, Takeda Y, Nada S, Koyama S, Takamatsu H, Kang S, Ito D, Maeda Y, Nishide M, Nojima S, Sarashina-Kida H, Hosokawa T, Kinehara Y, Kato Y, Nakatani T, Nakanishi Y, Tsuda T, Koba T, Okada M, and *Kumanogoh A. Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB. J Immunol. 200: 3790-3800 (2018) 査読有
岡田 雅人(大阪大学・微生物病研究所)
Hao F, Kondo K, Itoh T, Ikari S, Nada S, Okada M, *Noda T. Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi-lysosome contact site. J Cell Sci. 131, 208017 (2018) 査読有
松本 雅記 (九州大学・生体研)
Watanabe, S., Fujiyama, H., Takafuji, T., Kayama, K, Matsumoto, M., Nakayama, K.I., Yoshida, K., Sugimoto, N., Fujita, M. Glutamate-rich WD40 repeat containing 1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system. J Cell Sci. pii: jcs.213009 (2018) . 査読あり
松本 雅記 (九州大学・生体研)
Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K.I., Cohen, S.M., Tanaka, T., Rothenberg, E.V. Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding. Immunity 48, 1119-1134 (2018). 査読あり
松本 雅記 (九州大学・生体研)
Morita, M., Sato, T, Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A., Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K.I., Watanabe, T., Soga, T., Shima, H., Maemondo, M., and *Tanuma, N. PKM1 confers metabolic advantages and promotes cell-autonomous tumor cell growth. Cancer Cell 33,355-367 (2018). 査読あり
橋本 博(静岡県立大学・薬学部)
Hara, K., Uchida, M., Tagata, R., Yokoyama, H., Ishikawa, Y., Hishiki, A. and *Hashimoto, H.  Structure of proliferating cell nuclear antigen (PCNA) bound to AlkB homolog 2 PCNA-binding motif (APIM) reveals universality of PCNA-interaction. Acta Crystallogr. F74, 214-221 (2018). 査読有
橋本 博(静岡県立大学・薬学部)
Kishimoto S, Hara K, Hashimoto H, Hirayama Y, Champagne PA, Houk KN, Tang Y, Watanabe K.  Enzymatic one-step ring contraction for quinolone biosynthesis.  Nat Commun. 2018 Jul 19;9(1):2826. doi: 10.1038/s41467-018-05221-5.
高橋 明格(沖縄科学技術大学院大学)
Yamaguchi, T., Suzuki, T., Sato, T., Takahashi, A., Watanabe, H., Kadowaki, A., Natsui, M., Inagaki, H., Arakawa, S., Nakaoka, S., Koizumi, Y., Seki, S., Adachi, S., Fukao, A., Fujiwara, T., Natsume, T., Kimura, A., Komatsu, M., Shimizu, S., Ito, H., Suzuki, Y., Penninger, J.M., Yamamoto, T., Imai, Y., Kuba, K. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci. Signal. 11, pii: eaan3638. doi: 10.1126/scisignal.aan3638. (2018). 査読有
伊東 剛(東京大学・医科学研究所)
 Ito T, Kasai Y, Kumagai Y, Suzuki D, Ochiai-Noguchi M, Irikura D, Miyake S, Murakami Y. Quantitative analysis of interaction between CADM1 and its binding cell-surface proteins using surface plasmon resonance imaging. Front Cell Dev Biol, 6: 86, 2018. (in press) 査読有
doi: 10.3389/fcell.2018.00086
田中 剛平(東京大学・工学系研)
Tanaka, G, Dominguez-Huttinger, E., Christodoulides, P., Aihara, K., and Tanaka R. J. Bifurcation analysis of a mathematical model of atopic dermatitis to determine patient-specific effects of treatments on dynamic phenotypes. Journal of Theoretical Biology 448, 66-79 (2018). 査読有
難波 大輔(東京医科歯科大学・難治研)
難波大輔、*松崎恭一:重症下肢虚血における表皮角化幹細胞のクローナル・コンバージョンに関する研究への取り組み 形成外科、Vol. 60, 1264-1274 (2017). (査読有)
岩楯 好昭(山口大学・創成科学研究科)
Okimura, C., Sakumura, Y., Shimabukuro, K. and Iwadate, Y. Sensing of substratum rigidity and directional migration by fast-crawling cells. Phys. Rev. E 97, 052401. (2018) 査読有
池ノ内 順一(九州大学・理学系)
Matsuzawa K,Himoto T,Mochizuki Y, Ikenouchi J.
α-Catenin Controls the Anisotropy of Force Distribution at Cell-Cell Junctions during Collective Cell Migration.
Cell Rep. 23(12):3447-3456. (2018)
池ノ内 順一(九州大学・理学系)
Tsuchiya M, Hara Y, Okuda M, Itoh K, Nishioka R, Shiomi A, Nagao K, Mori M, Mori Y, Ikenouchi J, Suzuki R, Tanaka M, Ohwada T, Aoki J, Kanagawa M, Toda T, Nagata Y, Matsuda R, Takayama Y, Tominaga M, Umeda M. Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation. Nat Commun. 9(1):2049. (2018)
池ノ内 順一(九州大学・理学系)
Adherens junctions influence tight junction formation via changes in membrane lipid composition. Shigetomi K, Ono Y, Inai T, Ikenouchi J.
J Cell Biol. 217(7):2373-2381. (2018)
池ノ内 順一(九州大学・理学系)
Regulation of the epithelial barrier by post-translational modifications of tight junction membrane proteins.
Shigetomi K, Ikenouchi J.
J Biochem. 163(4):265-272. (2018)
岩本 一成(理研)
Magi, S., Iwamoto, K., Yumoto, N., Hiroshima, M., Nagashima, T., Ohki, R., Garcia-Munoz, A., Volinsky, N., Kriegsheim, VA., Sako, Y., Takahashi, K., Kimura, S., *Kholodenko BN., *Okada-Hatakeyama, M., Transcriptionally inducible Pleckstrin homology-like domain, family A, member 1, attenuates ErbB receptor activity by inhibiting receptor oligomerization, JBC 293(6), 2206–2218 (2018). 査読有
渡部 昌(北海道大学・医学系研)
Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Watanabe, M., and *Hatakeyama, S.: Anti-Sez6l2 antibody, detected in a patient with immune-mediated cerebellar ataxia, inhibits complex formation of GluR1 and Sez6l2. J. Neurol., 265(4), 962-965(2018).
渡部 昌(北海道大学・医学系研)
*Yabe, I., Yaguchi, H., Kato, Y., Miki, Y., Takahashi, H., Tanikawa, S., Shirai, S., Takahashi, I., Kimura, M., Hama, Y., Matsushima, M., Fujioka, S., Kano, T., Watanabe, M., Nakagawa, S., Kunieda, Y., Ikeda, Y., Hasegawa, M., Nishihara, H., Ohtsuka, T., Tanaka, S., Tsuboi, Y., Hatakeyama, S., Wakabayashi, K. and Sasaki, H. Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome.  Sci. Rep., 8, 819(2018).
堀 雄一郎(大阪大学・工学系研)
Hori, Y., Otomura, N., Nishida, A., Nishiura, M., Umeno, M., Suetake, I., *Kikuchi, K. Synthetic-molecule/protein hybrid probe with fluorogenic switch for live-cell imaging of DNA methylation. J. Am. Chem. Soc. 140, 1686-1690 (2018) 査読有
末次 志郎 (奈良先端科技大・バイオ研)
Nishimura, T., Morone, N. Suetsugu, S.
Membrane re-modelling by BAR domain superfamily proteins via molecular and non-molecular factors.
Biochem Soc Trans 46, 379-389 (2018) 査読有
末次 志郎 (奈良先端科技大・バイオ研)
西村珠子、末次志郎:BARドメインタンパク質と細胞骨格による細胞膜の構造構築  生体の科学 69(3):1─5,2018
末次 志郎 (奈良先端科技大・バイオ研)
北又学、木田和輝、末次志郎 :生体膜のリポクオリティとタンパク質ドメインによる認識 実験医学増刊号『脂質が支えるバイオロジー』 羊土社 2018
小柳 光正 (大阪市立大学・理学系)
Gerrard, E., Mutt, E., Nagata, T., Koyanagi, M., Flock, T., Lesca, E., Schertler, G., *Terakita, A., *Deupi, X., and *Lucas, R.  Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish. Proc. Natl. Acad. Sci. USA 115(24):6201-6206 (2018). 査読有
小柳 光正 (大阪市立大学・理学系)
Nagata, T., Koyanagi, M., Lucas, R., and *Terakita, A.  An all- trans -retinal-binding opsin peropsin as a potential dark-active and light-inactivated G protein-coupled receptor. Scientific Reports 8(1), 3535 (2018). 査読有
佐甲 靖志(国立研究開発法人理化学研究所)
Maeda, R., Hiroshima, M., Yamashita, T., Wada, A., Sako, Y., Shichida, Y. and *Imamoto, Y.  Shift in conformational equilibrium induces constitutive activity of G-Protein coupled receptor, rhodopsin. J. Phys. Chem. B. in press. 査読有
佐甲 靖志(国立研究開発法人理化学研究所)
Magi, S., Iwamoto, K., Yumono, N., Hiroshima, M., Nagashima, T., Ohki, R., Garcia-Munoz, A., Volinsky, N., Von Kriegsheim, A., Sako, Y., Takahashi, K., Kimura, S., Kholodenko, B. N. and *Okada-Hatakeyama, M.  Transcriptionally inducible Pleckstrin homology-like domain family A member 1 attenuates ErbB receptor activity by inhibiting receptor oligomerization. J. Biol. Chem. 293, 2206-2218 (2018). 査読有
佐甲 靖志(国立研究開発法人理化学研究所)
Maeda, R., Sato, T., Okamoto, K., Yanagawa, M. and *Sako, Y.  Lipid-protein interplay in dimerization of the juxtamembrane domains of epidermal growth factor receptor. Biophys. J. 114, 893-903 (2018). 査読有
佐甲 靖志(国立研究開発法人理化学研究所)
Hiroshima, M., Pack, C.-g., Kaizu, K., Takahashi, K., Ueda, M. and *Sako, Y.  Transient acceleration of epidermal growth factor receptor dynamics produces higher-order signaling clusters. J. Mol. Biol. 430, 1386-1401 (2018). 査読有
佐甲 靖志(国立研究開発法人理化学研究所)
Shindo, Y., Kondo, Y. and *Sako, Y.  Inferring a nonlinear biochemical network model from a heterogeneous single-cell time course data. Sci. Rep. 8. 6790 (2018). 査読有
大戸 梅治 (東京大学・薬学研)
Sakurai, S., *Shimizu, T., & *Ohto, U.
"The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription."
J. Biol. Chem. 292, 17609-17616 (2017)
大戸 梅治 (東京大学・薬学研)
Okamoto, N., Mizote, K., Honda, H., Saeki, A., Watanabe, Y., Yamaguchi-Miyamoto, T., Fukui, R., Tanimura, N., Motoi, Y., Akashi-Takamura, S., Kato, T., Fujishita, S., Kimura, T., Ohto, U., Shimizu, T., Hirokawa, T., Miyake, K., Fukase, K., Fujimoto, Y., *Nagai, Y., *Takatsu, K. "Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex." J. Biol. Chem. 292, 15378-15394 (2017)
大戸 梅治 (東京大学・薬学研)
Zhang, Z., Ohto, U., & *Shimizu, T.
"Towards a structural understanding of nucleic acid-sensing Toll-like receptors in the innate immune system."
FEBS letters. 591, 3167-3181 (2017)
大戸 梅治 (東京大学・薬学研)
*Ohto, U. "Conservation and Divergence of Ligand Recognition and Signal Transduction Mechanisms in Toll-Like Receptors."
Chem. Pharm. Bull. 65, 697-705 (2017)
大戸 梅治 (東京大学・薬学研)
Murakami, K., Nakano, K., *Shimizu, T., & *Ohto, U.
"The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family."
Acta Crystallogr F Struct Biol Commun. 73, 347-355. (2017)
五島 剛太 (名古屋大学・理学系)
Kosetsu K, Murata T, Yamada M, Nishina M, Boruc J, Hasebe M, *Van Damme D, *Goshima G.  Cytoplasmic MTOCs control spindle orientation for asymmetric cell division in plants. Proc Natl Acad Sci U S A. 114(42), E8847-E8854 (2017). 査読有
五島 剛太 (名古屋大学・理学系)
Tungadi EA, Ito A, Kiyomitsu T, *Goshima G.  Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2.  J. Cell Sci. 130, 3676-3684 (2017). 査読有
五島 剛太 (名古屋大学・理学系)
Beaven R, Bastos RN, Spanos C, Romé P, Cullen CF, Rappsilber J, Giet R, Goshima G, *Ohkura H.  14-3-3 regulation of Ncd reveals a new mechanism for targeting proteins to the spindle in oocytes. J. Cell Biol. 216(10), 3029 (2017). 査読有
五島 剛太 (名古屋大学・理学系)
Yamada M, Tanaka-Takiguchi Y, Hayashi M, Nishina M, *Goshima G.  Multiple kinesin-14 family members drive microtubule minus-end-directed transport in plant cells. J. Cell Biol. 216(6), 1705-1714 (2017). 査読有
五島 剛太 (名古屋大学・理学系)
de Keijzer J, Kieft H, Ketelaar T, Goshima G, *Janson ME.  Shortening of microtubule overlap regions defines membrane delivery sites during plant cytokinesis. Curr Biol. pii: S0960-9822(16)31524-X (2017). 査読有
岡田 雅人(大阪大学・微生物病研究所)
Yonehara R, Nada S, Nakai T, Nakai M, Kitamura A, Ogawa A, Nakatsumi H, Nakayama KI, Li S, Standley DM, Yamashita E, Nakagawa A, and *Okada M. Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun. 8, 1625 (2017) 査読有
岡田 雅人(大阪大学・微生物病研究所)
Hosokawa T, *Kimura T, Nada S, Okuno T, Ito D, Kang S, Nojima S, Yamashita K, Nakatani T, Hayama Y, Kato Y, Kinehara Y, Nishide M, Mikami N, Koyama S, Takamatsu H, Okuzaki D, Ohkura N, Sakaguchi S, Okada M, *Kumanogoh A. Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function. J Immunol. 199, 2008-2019 (2017) 査読有
齊藤 達哉(徳島大学・先端酵素学研究所)
Takahama M, Fukuda M, Ohbayashi N, Kozaki T, Misawa T, Okamoto T, Matsuura Y, Akira S, *Saitoh T. The RAB2B-GARIL5 complex promotes cytosolic DNA-induced innate immune responses. Cell Rep. 20, 2944-2954(2017). 査読有
齊藤 達哉(徳島大学・先端酵素学研究所)
Sasai M, Sakaguchi N, Ma JS, Nakamura S, Kawabata T, Bando H, Lee Y, Saitoh T, Akira S, Iwasaki A, Standley DM, Yoshimori T, *Yamamoto M. Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense. Nat Immunol. 18, 899-910(2017). 査読有
松本 雅記 (九州大学・生体研)
Nakatsumi, H., Matsumoto, M., and *Nakayama, K.I. Noncanonical pathway for regulation of CCL2 expression by an mTORC1-FOXK1 axis promotes recruitment of tumor-associated macrophages. Cell Rep. 21, 2471-2486 (2017). 査読あり
松本 雅記 (九州大学・生体研)
Robotic crowd biology with Maholo LabDroids. Yachie, N. Robotic Biology consortium (include Matsumoto, M and Nakayama K.I.), and *Natsume, T. Nature Biotechnol. 35, 310-312 (2017) 査読あり
松本 雅記 (九州大学・生体研)
Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, K.I., Watanabe, M., *Hatakeyama, S. Sez6l2 regulates phosphorylation of ADD and neuritogenesis. Biochem Biophys Res Commun. 494, 234-241 (2017) 査読あり
松本 雅記 (九州大学・生体研)
Kita, K., *Shiota, M., Tanaka, M., Otsuka, A., Matsumoto, M., Kato, M., Tamada, S., Iwao, H., Miura, K., Nakatani, T., Tomita, S. Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells. Cancer Sci. 108, 1820-1827 (2017) 査読あり
松本 雅記 (九州大学・生体研)
Cui, L., *Nakano, K., Obchoei, S., Setoguchi, K., Matsumoto, M., Yamamoto, T., Obika, S., Shimada K., Hiraoka, N.  Small nucleolar noncoding RNA SNORA23, up-regulated in human pancreatic ductal adenocarcinoma, regulates expression of spectrin repeat-containing nuclear envelope 2 to promote growth and metastasis of xenograft tumors in mice. Gastroenterology. 153, 292-306 (2017) 査読あり
松本 雅記 (九州大学・生体研)
Matsumoto, M., Matsuzaki, F., Oshikawa, K., Goshima, N., Mori, M., Kawamura Y., Ogawa K., Fukuda, E., Nakatsumi, H., Natsume, T., Fukui, K, Horimoto, K., Nagashima, T., Funayama, R., Nakayama, K., *Nakayama, K.I. A large-scale targeted proteomics assay resource based on an in vitro human proteome. Nature Methods 14, 251-258 (2017) 査読あり
松本 雅記 (九州大学・生体研)
Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A, Nakayama, K.I., Clohessy, J.G., *Pandolfi, P.P. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. Nature 541, 228-232 (2017) 査読あり
松本 雅記 (九州大学・生体研)
Okuda, S., Watanabe, Y., Moriya, Y., Kawano, S., Yamamoto, T., Matsumoto, M., Takami, T., Kobayashi, D., Araki, N., Yoshizawa, A.C., Tabata, T., Sugiyama, N., Goto., S, *Ishihama, Y. jPOSTrepo: an international standard data repository for proteomes. Nucleic Acids Res. 45, D1107-D1111 (2017) 査読あり
松本 雅記 (九州大学・生体研)
Kayama, K., Watanabe, S., Takafuji, T., Tsuji, T., Hironaka, K., Matsumoto, M., Nakayama, K.I., Enari, M., Kohno, T., Shiraishi, K., Kiyono, T., Yoshida, K., Sugimoto, N., Fujita, M. GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis. EMBO Rep. 18, 123-137 (2017) 査読あり
橋本 博(静岡県立大学・薬学部)
Hara, K., Taharazako, S., Ikeda, M., Fujita, F., Mikami, Y., Kikuchi, S., Hishiki, A., Yokoyama, H., Ishikawa, Y., Kanno, S., Tanaka, K. and *Hashimoto, H.  Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment maintaining phosphoprotein (CAMP). J. Biol. Chem. 292, 17658-17667 (2017). 査読有
橋本 博(静岡県立大学・薬学部)
Konishi, H., Matsubara, M., Mori, K., Tokiwa, T., Arulmozhiraja, S., Yamamoto, Y., Ishikawa, Y., Hashimoto, H., Shigeta, Y., Tokiwa, T. and *Manabe, K.  Mechanistic Insight into Weak-Base-Catalyzed Generation of Carbon Monoxide from Phenyl Formate and Its Application to Catalytic Carbonylation at Room Temperature without Use of External Carbon Monoxide Gas. Adv. Syn. Cat. 359, 3592-3601 (2017). 査読有
橋本 博(静岡県立大学・薬学部)
Oda,T., Hirabayashi, H., Shikauchi, G., Takamura, R., Hiraga, K., Minami, H., Hashimoto, H., Yamamoto, M., Wakabayashi, K., Shimizu, T. and *Sato, M.  Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1. J. Biol. Chem. 292, 15445-15455 (2017). 査読有
高橋 明格(沖縄科学技術大学院大学)
Li, X., Morita, M., Kikuguchi, C., Takahashi, A., Suzuki, T., Yamamoto, T. (2017). Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy. FEBS Lett. 591, 358-368. 査読有
中村 直俊 (京都大学)
Akiyama K, Nakamura N, Itatani K, Naito Y, Kinoshita M, Shimizu M, Hamaoka S, Kato H, Yasumoto H, Nakajima Y, Mizobe T, Numata S, Yaku H, Sawa T. Flow-dynamics assessment of mitral-valve surgery by intraoperative vector flow mapping. Interact Cardiovasc Thorac Surg 24, 869-875 (2017). 査読有
中村 直俊 (京都大学)
Akiyama K, Maeda S, Matsuyama T, Kainuma A, Ishii M, Naito Y, Kinoshita M, Hamaoka S, Kato H, Nakajima Y, Nakamura N, Itatani K, Sawa T. Vector flow mapping analysis of left ventricular energetic performance in healthy adult volunteers. BMC Cardiovasc Disord 17, 21 (2017). 査読有
末次 志郎 (奈良先端科技大・バイオ研)
Tachikawa M, Morone N, Senju Y, Sugiura T, Hanawa-Suetsugu K, Mochizuki A, Suetsugu S.
Measurement of caveolin-1 densities in the cell membrane for quantification of caveolar deformation after exposure to hypotonic membrane tension.
Sci Rep 7, 7794 (2017) 査読有
末次 志郎 (奈良先端科技大・バイオ研)
Takemura K, Hanawa-Suetsugu K, Suetsugu S, Kitao A.
Salt Bridge Formation between the I-BAR Domain and Lipids Increases Lipid Density and Membrane Curvature.
Sci Rep7, 6808 (2017) 査読有
末次 志郎 (奈良先端科技大・バイオ研)
Dumont V, Tolvanen TA, Kuusela S, Wang H, Nyman TA, Lindfors S, Tienari J, Nisen H, Suetsugu S, Plomann M, Kawachi H, Lehtonen S.
PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease.
FASEB J. 31, 3978-3990 (2017) 査読有
池ノ内 順一(九州大学・理学系)
Kinoshita M, Ano H, Murata M, Shigetomi K, Ikenouchi J, Matsumori N.
Emphatic visualization of sphingomyelin-rich domains by inter-lipid FRET imaging using fluorescent sphingomyelins.
Sci Rep. 7(1):16801 (2017)
渡部 昌(北海道大学・医学系研)
Watanabe, M. and *Hatakeyama, S.: TRIM proteins and diseases. J. Biochem., 161, 135-144(2017).
渡部 昌(北海道大学・医学系研)
Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, KI., Watanabe, M. and *Hatakeyama, S.: Sez6l2 regulates phosphorylation of ADD and neuritogenesis. Biochem. Biophys. Res. Commun., 494, 234-241(2017).
堀 雄一郎(大阪大学・工学系研)
Hori, Y., Hirayama, S., Kikuchi, K. Development of cyanine probes with dinitrobenzene quencher for rapid fluorogenic protein labelling. Philos. Trans. A Math. Phys. Eng. Sci. 375. pii: 20170018 (2017) 査読有
小柳 光正 (大阪市立大学・理学系)
Matsuo, R., Takatori, Y., Hamada, S., Koyanagi, M., and *Matsuo, Y.  Expression and light-dependent translocation of β-arrestin in the visual system of the terrestrial slug Limax valentianus. J Exp Biol.220(Pt 18):3301-3314 (2017). 査読有
佐甲 靖志(国立研究開発法人理化学研究所)
Sumi, M., Makino, A., Inaba, T., Sako, Y., Fujimori, F., Greimel, P. and *Kobayashi, T.  Photoswitchable phospholipid FRET acceptor: Detergent free intermembrane transfer assay of fluorescent lipid analogs. Sci. Rep. 7, 2900 (2017). 査読有
佐甲 靖志(国立研究開発法人理化学研究所)
Yoshizawa, R., *Umeki, N., Yanagawa, M., Murata, M. and *Sako, Y.  Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction to Ras to Ral. Biophys. Physicobiol. 14, 75-84 (2017). 査読有
佐甲 靖志(国立研究開発法人理化学研究所)
Nakamura, Y.,Umeki, N., Abe M. and *Sako, Y.  Mutation-specific mechanisms of hyperactivation of Noonan syndrome SOS molecules detected with single-molecule imaging in living cells. Sci. Rep. 7 (2017). 査読有
2018.4.19 岩楯 好昭(山口大学・創成科学研究科)
Okimura, C., Sakumura, Y., Shimabukuro, K. and Iwadate, Y.
Sensing of substratum rigidity and directional migration by fast-crawling cells
Physical Review E 97: 052401 (2018). doi:10.1103/PhysRevE.97.052401 [URL]
2018.4.19 岡田 雅人(大阪大学・微生物病研究所)
Yonehara R, Nada S, Nakai T, Nakai M, Kitamura A, Ogawa A, Nakatsumi H, Nakayama KI, Li S, Standley DM, Yamashita E, Nakagawa A, Okada M.
Structuralbasis for the assembly of the Ragulator-Rag GTPase complex.
Nat Commun. 2017 Nov 20;8(1):1625. doi: 10.1038/s41467-017-01762-3. [PubMed]
2018.4.19 末次 志郎(奈良先端科技大・バイオ研)
Takemura K, Hanawa-Suetsugu K, Suetsugu S, Kitao A.
Salt Bridge Formation between the I-BAR Domain and Lipids Increases Lipid Density and Membrane Curvature.
Sci Rep. 2017 Jul 28;7(1):6808. doi: 10.1038/s41598-017-06334-5. [PubMed]
2018.4.19 末次 志郎(奈良先端科技大・バイオ研)
Tachikawa M, Morone N, Senju Y, Sugiura T, Hanawa-Suetsugu K, Mochizuki A, Suetsugu S.
Measurement of caveolin-1 densities in the cell membrane for quantification of caveolar deformation after exposure to hypotonic membrane tension.
Sci Rep. 2017 Aug 10;7(1):7794. doi: 10.1038/s41598-017-08259-5. [PubMed]
2017.11.15 橋本 博(静岡県立大学 薬学部)
Hara K, Taharazako S, Ikeda M, Fujita H, Mikami Y, Kikuchi S, Hishiki A, Yokoyama H, Ishikawa Y, Kanno SI, Tanaka K, Hashimoto H. Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment maintaining phosphoprotein (CAMP). J Biol Chem (2017) 292, 17658. [PubMed]
2017.8.22
論文解説
石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Reiya Taniguchi, Asuka Inoue, Misa Sayama, Akiharu Uwamizu, Keitaro Yamashita, Kunio Hirata, Masahito Yoshida, Yoshiki Tanaka, Hideaki E. Kato, Yoshiko Nakada-Nakura, Yuko Otani, Tomohiro Nishizawa, Takayuki Doi, Tomohiko Ohwada, Ryuichiro Ishitani, Junken Aoki & Osamu Nureki
Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6.
Nature 548, 356-360 (17 August 2017) doi:10.1038/nature23448 [PubMed]
http://www.nature.com/nature/journal/v548/n7667/full/nature23448.html
2017.8.14 仁科博史(東京医科歯科大学・難治疾患研究所)
Tokiwa Yamasaki, Norie Deki-Arima, Asahito Kaneko, Norio Miyamura, Mamiko Iwatsuki, Masato Matsuoka, Noriko Fujimori-Tonou, Yoshimi Okamoto-Uchida, Jun Hirayama, Jamey D. Marth, Yuji Yamanashi, Hiroshi Kawasaki, Koji Yamanaka, Josef M. Penninger, Shigenobu Shibata and Hiroshi Nishina (2017)
Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7.
Scientific Reports
7, 7348. [PubMed]
2017.6.23 鈴木 貴(大阪大学大学院基礎工学研究科)
S. Kawasaki, D. Minerva, K. Itano, T. Suzuki,
Finding solvable units of variables in nonlinear ODEs of ECM degradation pathway network,
Comp. Math. Mech. Machine [PubMed]
https://doi.org/10.1155/2017/5924270
2017.5.16 石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Kato K, Omura H, Ishitani R, Nureki O.
Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.
Annu Rev Biochem. 2017 Apr 7. doi: 10.1146/annurev-biochem-061516-044813. [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Hashimoto T, Horikawa DD, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T, Enomoto A, Kondo K, Tanaka S, Hara Y, Koshikawa S, Sagara H, Miura T, Yokobori S, Miyagawa K, Suzuki Y, Kubo T, Oyama M, Kohara Y, Fujiyama A, Arakawa K, Katayama T, Toyoda A, and Kunieda T.
Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein.
Nat. Commun. 7: 12808 (2016) [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
井上純一郎(東京大・医科研・分子発癌分野)
Narushima Y, Kozuka-Hata H, Tsumoto K, Inoue J, and Oyama M.
Quantitative phosphoproteomics-based molecular network description for high-resolution kinase-substrate interactome analysis.
Bioinformatics 32: 2083-2088 (2016) [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Hirano A, Nakagawa T, Yoshitane H, Oyama MKozuka-Hata H, Lanjakornsiripan D, and Fukada Y.
USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock.
PLoS One 11: e0154263 (2016) [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, and Kiyono H. 
Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody. 
Regul. Toxicol. Pharmacol. 76: 128-136 (2016) [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Nishimura A, Yamamoto K, Oyama MKozuka-Hata H, Saito H, and Tatebayashi K. 
Scaffold Protein Ahk1, Which Associates with Hkr1, Sho1, Ste11, and Pbs2, Inhibits Cross Talk Signaling from the Hkr1 Osmosensor to the Kss1 Mitogen-Activated Protein Kinase.
Mol. Cell. Biol. 36: 1109-1123 (2016) [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Taniue K, Kurimoto A, Sugimasa H, Nasu E, Takeda Y, Iwasaki K, Nagashima T, Okada-Hatakeyama M, Oyama MKozuka-Hata H, Hiyoshi M, Kitayama J, Negishi L, Kawasaki Y, and Akiyama T.
Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1. 
Proc. Natl. Acad. Sci. USA 113: 1273-1278 (2016) [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Sato Y, Kato A, Maruzuru Y, Oyama MKozuka-Hata H, Arii J, and Kawaguchi Y.
Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication.
J. Virol. 90: 3173-3186 (2016)[PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
井上純一郎(東京大・医科研・分子発癌分野)
Narushima Y, Kozuka-Hata H, Koyama-Nasu R, Tsumoto K, Inoue J, Akiyama T, and Oyama M.
Integrative Network Analysis Combined with Quantitative Phosphoproteomics Reveals TGFBR2 as a Novel Regulator of Glioblastoma Stem Cell Properties.
Mol. Cell. Proteomics 15: 1017-1031 (2016)[PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Sato Y, Kato A, Arii J, Koyanagi N, Kozuka-Hata HOyama M, and Kawaguchi Y. 
Ubiquitin-specific protease 9X in host cells interacts with herpes simplex virus 1 ICP0.
J. Vet. Med. Sci. 78: 405-410 (2016) [PubMed]
2017.2.7 徳永文稔(大阪市大・院医・分子病態学)
Yamamotoya T, Nakatsu T, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, and Sakoda H. Reduced SHARPIN and LUBAC formation may contribute to CCl4- or acetaminophen-induced liver cirrhosis in mice. Int. J. Mol. Sci.18, E326, (2017) [PubMed].
2017.2.6 井上純一郎(東京大・医科研・分子発癌分野)
Akiyama, N., Takizawa, N., Miyauchi, M., Yanai, H., Tateishi, R., Shinzawa, M., Yoshinaga, R., Kurihara, M., Demizu, Y., Yasuda, H., Yagi, S., Wu, G., Matsumoto, M., Sakamoto, R., Yoshida, N., Penninger, J.M., Kobayashi, Y., Inoue, J. and Akiyama, T.* Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. J. Exp. Med. 213(8):1441-58. doi: 10.1084/jem.20151780. (2016). [PubMed]
2017.2.6 井上純一郎(東京大・医科研・分子発癌分野)
Kawasaki, M., Kawasaki, K., Oommen, S., Blackburn, J., Watanabe, M., Nagai, T., Kitamura, A., Maeda, T., Liu, B., Schmidt-Ullrich, R., Akiyama, T., Inoue, J., Hammond, N.L., Sharpe, P.T. and Ohazama, A.* Regional regulation of filiform tongue papillae development by Ikka /Irf6. Dev. Dyn. doi: 10.1002/dvdy.24427 (2016). [PubMed]
2017.2.6 井上純一郎(東京大・医科研・分子発癌分野)
Yamamoto, M., Mastsuyama, S., Li, X., Takeda, M., Kawaguchi, Y., Inoue, J.* and Matsuda, Z.* Identification of nafamostat as a potent inhibitor of Middle East respiratory syndrome (MERS) corona virus S-mediated membrane fusion using the split protein-based cell-cell fusion assay. Antimicrob. Agents Chemother. 60(11):6532-6539. doi: 10.1128/AAC.01043-16 (2016). [PubMed]
2017.2.6 井上純一郎(東京大・医科研・分子発癌分野)
Yu, J., Yun, H., Shin, B., Kim, Y., Park, E.S., Choi, S., Yu, J., Amarasekara, D.S., Kim, S., Inoue, J., Walsh, M.C., Choi, Y., Takami, M. and Rho, J.* Interaction of tumor necrosis factor receptor-associated factor 6 (TRAF6) and Vav3 in the receptor activator of nuclear factor kB (RANK) signaling complex enhances osteoclastogenesis. J. Biol. Chem. (2016) 291(39):20643-60. doi: 10.1074/jbc.M116.728303. [PubMed]
2017.2.6 井上純一郎(東京大・医科研・分子発癌分野)
Varney, M., Choi, K., Bolanos, L., Christie, S., Fang, J., Grimes, L., Maciejewski, J., Inoue, J. and Starczynowski D. Epistasis between TIFAB and miR-146a, neighboring genes in del(5q) MDS. Leukemia (2017) 31, 491–495; doi:10.1038/leu.2016.276 [PubMed]
2017.2.6 井上純一郎(東京大・医科研・分子発癌分野)
徳永文稔(大阪市大・院医・分子病態学)
Shibata, Y., Tokunaga, F., Goto, E., Komatsu, G., Gohda, J., Saeki, Y., Tanaka, K., Takahashi, H., Sawasaki, T., Inoue, S., Oshiumi, H., Seya, T., Nakano, H., Tanaka, Y., Iwai, K. and Inoue, J. HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. PLoS Pathogens 13(1):e1006162. doi: 10.1371/journal.ppat.1006162 (2017). [PubMed]
2017.2.6 徳永文稔(大阪市大・院医・分子病態学)
Hattori M, Shimuzu A, Oikawa D, Kamei K, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Tokunaga F, Ishikawa O. ER stress in the pathogenesis of pretibial dystrophic epidermolysis bullosa. Br. J. Dermatol. (in press)[PubMed]
2017.2.6 徳永文稔(大阪市大・院医・分子病態学)
Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, and Nureki O. Structural and functional analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide. Sci. Rep. 6, 34756 (2016) [PubMed].
2017.2.6 徳永文稔(大阪市大・院医・分子病態学)
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, and Tokunaga F. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat. Commun. 7, 12547 (2016) [PubMed].
2017.2.6 徳永文稔(大阪市大・院医・分子病態学)
Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsnomiya A, Watanabe T, and Yamaoka S. A20 targets caspase-8 and FADD to protect HTLV-I infected cells. Leukemia, 30, 716-727 (2016) [PubMed].
2017.2.3 武川睦寛(東京大・医科研・分子シグナル制御分野)
Arimoto-Matsuzaki K, Saito H and Takekawa M.
TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis.
Nature Communications 7: 10252 doi:10.1038/ncomms10252 (2016) [PubMed]
2017.2.3 武川睦寛(東京大・医科研・分子シグナル制御分野)
Hijiya N, Tsukamoto Y, Nakada C, Tung NL, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, and Moriyama M.   
Genomic loss of DUSP4 contributes to the progression of intraepitherial neoplasm of pancreas to invasive carcinoma.
Cancer Research 76: 2612-2625 (2016) [PubMed]
2017.2.3 武川睦寛(東京大・医科研・分子シグナル制御分野)
Kinoshita E, Kinoshita-Kikuta E, Kubota Y, Takekawa M and Koike T.
A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1.
Proteomics 16:1825-1836 (2016) [PubMed]
2017.2.3 武川睦寛(東京大・医科研・分子シグナル制御分野)
Kubota Y and Takekawa M
Detection and functional analysis of SUMO-modified MEK. 
Methods in Molecular Biology 1487, 99-111 (2016) [PubMed]
2017.2.3 武川睦寛(東京大・医科研・分子シグナル制御分野)
武川睦寛
MAPキナーゼ情報伝達経路の活性制御機構と疾患発症機構の解明
生物物理化学 60巻 7-10 (2016). [URL]

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