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研究成果

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研究成果

2017.6.23 鈴木 貴(大阪大学大学院基礎工学研究科)
S. Kawasaki, D. Minerva, K. Itano, T. Suzuki,
Finding solvable units of variables in nonlinear ODEs of ECM degradation pathway network,
Comp. Math. Mech. Machine [PubMed]
https://doi.org/10.1155/2017/5924270
2017.5.16 石谷隆一郎(東京大学大学院理学系研究科・生物科学専攻)
Kato K, Omura H, Ishitani R, Nureki O.
Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.
Annu Rev Biochem. 2017 Apr 7. doi: 10.1146/annurev-biochem-061516-044813. [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Hashimoto T, Horikawa DD, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T, Enomoto A, Kondo K, Tanaka S, Hara Y, Koshikawa S, Sagara H, Miura T, Yokobori S, Miyagawa K, Suzuki Y, Kubo T, Oyama M, Kohara Y, Fujiyama A, Arakawa K, Katayama T, Toyoda A, and Kunieda T.
Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein.
Nat. Commun. 7: 12808 (2016) [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
井上純一郎(東京大・医科研・分子発癌分野)
Narushima Y, Kozuka-Hata H, Tsumoto K, Inoue J, and Oyama M.
Quantitative phosphoproteomics-based molecular network description for high-resolution kinase-substrate interactome analysis.
Bioinformatics 32: 2083-2088 (2016) [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Hirano A, Nakagawa T, Yoshitane H, Oyama MKozuka-Hata H, Lanjakornsiripan D, and Fukada Y.
USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock.
PLoS One 11: e0154263 (2016) [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, and Kiyono H. 
Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody. 
Regul. Toxicol. Pharmacol. 76: 128-136 (2016) [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Nishimura A, Yamamoto K, Oyama MKozuka-Hata H, Saito H, and Tatebayashi K. 
Scaffold Protein Ahk1, Which Associates with Hkr1, Sho1, Ste11, and Pbs2, Inhibits Cross Talk Signaling from the Hkr1 Osmosensor to the Kss1 Mitogen-Activated Protein Kinase.
Mol. Cell. Biol. 36: 1109-1123 (2016) [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Taniue K, Kurimoto A, Sugimasa H, Nasu E, Takeda Y, Iwasaki K, Nagashima T, Okada-Hatakeyama M, Oyama MKozuka-Hata H, Hiyoshi M, Kitayama J, Negishi L, Kawasaki Y, and Akiyama T.
Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1. 
Proc. Natl. Acad. Sci. USA 113: 1273-1278 (2016) [PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Sato Y, Kato A, Maruzuru Y, Oyama MKozuka-Hata H, Arii J, and Kawaguchi Y.
Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication.
J. Virol. 90: 3173-3186 (2016)[PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
井上純一郎(東京大・医科研・分子発癌分野)
Narushima Y, Kozuka-Hata H, Koyama-Nasu R, Tsumoto K, Inoue J, Akiyama T, and Oyama M.
Integrative Network Analysis Combined with Quantitative Phosphoproteomics Reveals TGFBR2 as a Novel Regulator of Glioblastoma Stem Cell Properties.
Mol. Cell. Proteomics 15: 1017-1031 (2016)[PubMed]
2017.2.8 尾山大明、秦 裕子(東京大・医科研・疾患プロテオミクスラボラトリー)
Sato Y, Kato A, Arii J, Koyanagi N, Kozuka-Hata HOyama M, and Kawaguchi Y. 
Ubiquitin-specific protease 9X in host cells interacts with herpes simplex virus 1 ICP0.
J. Vet. Med. Sci. 78: 405-410 (2016) [PubMed]
2017.2.7 徳永文稔(大阪市大・院医・分子病態学)
Yamamotoya T, Nakatsu T, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, and Sakoda H. Reduced SHARPIN and LUBAC formation may contribute to CCl4- or acetaminophen-induced liver cirrhosis in mice. Int. J. Mol. Sci.18, E326, (2017) [PubMed].
2017.2.6 井上純一郎(東京大・医科研・分子発癌分野)
Akiyama, N., Takizawa, N., Miyauchi, M., Yanai, H., Tateishi, R., Shinzawa, M., Yoshinaga, R., Kurihara, M., Demizu, Y., Yasuda, H., Yagi, S., Wu, G., Matsumoto, M., Sakamoto, R., Yoshida, N., Penninger, J.M., Kobayashi, Y., Inoue, J. and Akiyama, T.* Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. J. Exp. Med. 213(8):1441-58. doi: 10.1084/jem.20151780. (2016). [PubMed]
2017.2.6 井上純一郎(東京大・医科研・分子発癌分野)
Kawasaki, M., Kawasaki, K., Oommen, S., Blackburn, J., Watanabe, M., Nagai, T., Kitamura, A., Maeda, T., Liu, B., Schmidt-Ullrich, R., Akiyama, T., Inoue, J., Hammond, N.L., Sharpe, P.T. and Ohazama, A.* Regional regulation of filiform tongue papillae development by Ikka /Irf6. Dev. Dyn. doi: 10.1002/dvdy.24427 (2016). [PubMed]
2017.2.6 井上純一郎(東京大・医科研・分子発癌分野)
Yamamoto, M., Mastsuyama, S., Li, X., Takeda, M., Kawaguchi, Y., Inoue, J.* and Matsuda, Z.* Identification of nafamostat as a potent inhibitor of Middle East respiratory syndrome (MERS) corona virus S-mediated membrane fusion using the split protein-based cell-cell fusion assay. Antimicrob. Agents Chemother. 60(11):6532-6539. doi: 10.1128/AAC.01043-16 (2016). [PubMed]
2017.2.6 井上純一郎(東京大・医科研・分子発癌分野)
Yu, J., Yun, H., Shin, B., Kim, Y., Park, E.S., Choi, S., Yu, J., Amarasekara, D.S., Kim, S., Inoue, J., Walsh, M.C., Choi, Y., Takami, M. and Rho, J.* Interaction of tumor necrosis factor receptor-associated factor 6 (TRAF6) and Vav3 in the receptor activator of nuclear factor kB (RANK) signaling complex enhances osteoclastogenesis. J. Biol. Chem. (2016) 291(39):20643-60. doi: 10.1074/jbc.M116.728303. [PubMed]
2017.2.6 井上純一郎(東京大・医科研・分子発癌分野)
Varney, M., Choi, K., Bolanos, L., Christie, S., Fang, J., Grimes, L., Maciejewski, J., Inoue, J. and Starczynowski D. Epistasis between TIFAB and miR-146a, neighboring genes in del(5q) MDS. Leukemia (2017) 31, 491–495; doi:10.1038/leu.2016.276 [PubMed]
2017.2.6 井上純一郎(東京大・医科研・分子発癌分野)
徳永文稔(大阪市大・院医・分子病態学)
Shibata, Y., Tokunaga, F., Goto, E., Komatsu, G., Gohda, J., Saeki, Y., Tanaka, K., Takahashi, H., Sawasaki, T., Inoue, S., Oshiumi, H., Seya, T., Nakano, H., Tanaka, Y., Iwai, K. and Inoue, J. HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. PLoS Pathogens 13(1):e1006162. doi: 10.1371/journal.ppat.1006162 (2017). [PubMed]
2017.2.6 徳永文稔(大阪市大・院医・分子病態学)
Hattori M, Shimuzu A, Oikawa D, Kamei K, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Tokunaga F, Ishikawa O. ER stress in the pathogenesis of pretibial dystrophic epidermolysis bullosa. Br. J. Dermatol. (in press)[PubMed]
2017.2.6 徳永文稔(大阪市大・院医・分子病態学)
Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, and Nureki O. Structural and functional analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide. Sci. Rep. 6, 34756 (2016) [PubMed].
2017.2.6 徳永文稔(大阪市大・院医・分子病態学)
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, and Tokunaga F. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat. Commun. 7, 12547 (2016) [PubMed].
2017.2.6 徳永文稔(大阪市大・院医・分子病態学)
Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsnomiya A, Watanabe T, and Yamaoka S. A20 targets caspase-8 and FADD to protect HTLV-I infected cells. Leukemia, 30, 716-727 (2016) [PubMed].
2017.2.3 武川睦寛(東京大・医科研・分子シグナル制御分野)
Arimoto-Matsuzaki K, Saito H and Takekawa M.
TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis.
Nature Communications 7: 10252 doi:10.1038/ncomms10252 (2016) [PubMed]
2017.2.3 武川睦寛(東京大・医科研・分子シグナル制御分野)
Hijiya N, Tsukamoto Y, Nakada C, Tung NL, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, and Moriyama M.   
Genomic loss of DUSP4 contributes to the progression of intraepitherial neoplasm of pancreas to invasive carcinoma.
Cancer Research 76: 2612-2625 (2016) [PubMed]
2017.2.3 武川睦寛(東京大・医科研・分子シグナル制御分野)
Kinoshita E, Kinoshita-Kikuta E, Kubota Y, Takekawa M and Koike T.
A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1.
Proteomics 16:1825-1836 (2016) [PubMed]
2017.2.3 武川睦寛(東京大・医科研・分子シグナル制御分野)
Kubota Y and Takekawa M
Detection and functional analysis of SUMO-modified MEK. 
Methods in Molecular Biology 1487, 99-111 (2016) [PubMed]
2017.2.3 武川睦寛(東京大・医科研・分子シグナル制御分野)
武川睦寛
MAPキナーゼ情報伝達経路の活性制御機構と疾患発症機構の解明
生物物理化学 60巻 7-10 (2016). [URL]

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