第75回日本癌学会学術総会

第75回日本癌学会学術総会にて、本領域に関連するシンポジウム等が以下の様に開催されました。

概要

会期：2016年10月6−8日
会場：パシフィコ横浜

[IS1] インターナショナルセッション 1　統合数理腫瘍学の方法
Methods of integrative mathematical oncology

開催日：2016年10月6日（木）9:00-11:30
会場：Room 2
座長：鈴木 貴（大阪大・院・基礎工学）、Yu Shyr（Vanderbilt Ctr. for Quantitative Sci., Vanderbilt Univ. Med. Ctr.）

This international session is devoted to the methods of integrative mathematical oncology (IMO). It is extensively developing and twelve institutions join the Integrative Cancer Biology Program in the United States. Cancer Quantitative Science Center of Vanderbilt University contains three divisions, bio-informatics, systems biology, and bio-statistics. Professor Dr. Yu Shyr, the main guest of this session, is its head. IMO is divided into two parts, data science and mathematical modeling. First, an overview of IMO is illustrated by the organizer of this session. The next two speakers, Dr. Takashi Ito and Dr. Yao-Ting Huang will report on the use of mathematical modeling in the study of drug resistance and lung adenocarcinoma detection. Then, Dr. Kohei Kubo and Ms. Itano will talk on the methods of statistics in the study of protein dynamics and medical image visualization. The following two talks by Dr. Chen-Hsin Chen and Luonan Chen are concerned on the application of systems biology to cancer therapies. Professor Dr. Yu Shyr will finally address recent targets of integrative mathematical oncology.

IS1-1

Mathematical analysis of the role of CADM1 in the MET-driven resistance against gefitinib in lung adenocarcinoma

Takeshi Ito¹, Motoi Ohba², Takashi Suzuki³, Yoshinori Murakami¹ (¹Div. of Mol. Path., Inst. Of Med. Sci., The Univ. of Tokyo, ²Inst. of Mol. Oncol., Showa Univ., ³Div. of Math. Sci., Grad. Sch. Of Eng. Sci., Osaka Univ.)

MET遺伝子増幅型gefitinib耐性肺腺がんにおける細胞接着分子CADM1の機能の数理モデリング

伊東 剛¹、大場 基²、鈴木 貴³、村上 善則¹（¹東京大・医科研・人癌病因遺伝子、²昭和大・腫瘍分子生物研、³大阪大・基礎工・数理）

IS1-2

Early Detection of Lung Adenocarcinoma via 3D Structure Reconstruction from Low Dose Computed Tomography

Yao-Ting Huang¹, Kuo-Wei Chen¹, Jian-Wei Chen², Sung-Liang Yu³, Jean-Seng Tseng⁴, Chia-Hung Hsu⁴, Chi-Chen Chang⁴, Hsuan-Yu Chen⁵ (¹Dept. of Computer Sci. & Information Engineering, Natl. Chung Cheng Univ., ²Inst. of Biomed. Sci., Natl. Chung Hsing Univ., ³Dept. of Lab. Sci. & Med. Biotechnology, Natl. Taiwan Univ., ⁴Taichung Veterans General Hosp., ⁵Inst. of Statistical Sci., Academia Sinica)

IS1-3

Protein dynamics in response to genotoxic drugs regulated by proteasome system

Kohei Kume^1,2, Satoshi Nishizuka^1,2 (¹Mol. Therap. Lab., Dept. of Surg., Iwate Med. Univ. Sch. of Med., ²Inst. of Biomed. Sci. Iwate Med. Univ.)

DNA障害薬応答においてプロテアソーム系に制御されるタンパク動態

久米 浩平^1,2、西塚 哲^1,2（¹岩手医大・医・外科・分子治療、²岩手医大・医歯薬総合研）

IS1-4

Mathematical segmentation methods for visualization ns and its application and analysis to detecting lesions.

Keiko Itano (Dept. of Systems Innovation, Engineering Sci., Osaka Univ.)

数理的可視化手法と病変診断への応用・解析

板野 景子（大阪大・基礎工学・システム創成・数理）

IS1-5

Statistical Modeling for Progression to Cancer, Targeted Therapy and Cure

Chen-Hsin Chen^1,2 (¹Inst. of Statistical Sci., Academia Sinica, ²Grad. Inst. of Epidemiology and Prevention Med., Natl. Taiwan Univ.)

IS1-6

Molecular biomarkers, network biomarkers and dynamical network biomarkers for complex diseases

Luonan Chen (Shanghai Inst. for Life Sci., Chinease Academy of Sci.)

IS1-7

Statistical Aspects of Omics Data Analysis Using the Random Compound Covariate

Yu Shyr (Vanderbilt Ctr. for Quantitative Sci., Vanderbilt Univ. Med. Ctr.)

[S6] シンポジウム 6　がん化・悪性化の鍵となるシグナル伝達経路
Key signal transduction pathways in cancer development

開催日：2016年10月7日（金）12:50-15:20
会場：第14会場
座長：井上 純一郎（東京大・医科研・分子発癌）、一條 秀憲（東京大・院薬・細胞情報）

Signal transduction pathways are triggered by various ligand-receptor interactions and lead to modulation of gene expression profiles, which cell-autonomously or non-cell-autonomously regulate proliferation, differentiation and survival of cells. Therefore, proper regulation of signal transduction pathways plays critical roles in maintenance of the health of each of us, while their dysregulations likely cause onset and development of various diseases such as cancer. Needless to say, molecules involved in such pathways could be targets for anti-cancer interventions. In this symposium, we would like to focus on six key pathways involved in cancer development: two pathways that control tumor progression by killing tumor cells, alongside four pathways that promote tumor development. Precise molecular mechanisms of cancer development and therapeutic strategies based on each finding will be discussed.

S6-1

Non-canonical Warburg effect induces elimination of transformed cells from epithelia

Yasuyuki Fujita (Inst. for Genetics Med., Hokkaido Univ.)

細胞競合がもたらすワーブルグ効果様の代謝変化

藤田 恭之（北海道大・遺制研・分子腫瘍）

S6-2

What do we learn from cancer cell necrosis

Liming Sun (Inst. of Biochemistry & Cell Biol., CAS)

S6-3

Stress signaling in tumorigenesis and tumor metastasis

Miki Kamiyama, Isao Naguro, Hidenori Ichijo (Cell Signaling, Grad. Sch. of Pharm. Sci., The Univ. of Tokyo)

ストレスシグナル経路とがん進展

神山 美樹、名黒 功、一條 秀憲（東京大・院薬・細胞情報）

S6-4

Role of Akt-Girdin signaling in cancer progression

Masahide Takahashi, Atsushi Enomoto, Naoya Asai (Dept. of Pathol. Nagoya Univ. Grad. Sch. of Med.)

がんの進展におけるAkt-girdinシグナル伝達系の役割

高橋 雅英、榎本 篤、浅井 直也（名古屋大・院医・分子病理/腫瘍病理）

S6-5

Differential roles of NF-κB activation in mammary gland development and breast cancer malignancy

Mizuki Yamamoto¹, Jun-ichiro Inoue² (¹Res. Ctr. for Asian Infectious Diseases, IMSUT, ²Div. of Cell. & Mol. Biol., IMSUT)

乳腺発達と乳癌悪性化における転写因子NF-κBの役割の相違

山本 瑞生¹、井上 純一郎²（¹東京大・医科研・アジア感染症拠点、²東京大・医科研・分子発癌）

S6-6

Aberrant activation of signal transduction pathways in ATL cells

Toshiki Watanabe^1,2, Makoto Yamagishi², Kazumi Nakano², Kaoru Uchimaru² (¹Dept. of Advanced Med. Innovation., St. Marianna Univ., ²Lab. Tumor Cell Biol. Grad. Sch. of Frontier Sci., The Univ. of Tokyo)

ATL細胞におけるシグナル伝達系の異常な異常な活性化の機構と意義

渡邉 俊樹^1,2、山岸 誠²、中野 和民²、内丸 薫²（¹聖マリ医大・院・先端医療開発、²東京大・新領域・病態医療）

[IC1] がん研究入門コース 1

開催日：2016年10月8日（土）9:00-11:30
会場：第13会場
座長：稲葉 俊哉（広島大・原爆放射線医科研）、堺 隆一（北里大・医・生化学）

IC1-1

Curernt progress in cancer genomics and genetics

Koichi Matsuda (Grad. Sch. of Front. Sci., The Univ. of Tokyo.)

がんゲノム解析の基礎

松田 浩一（東京大・院・新領域創成）

IC1-2

The importance of chromatin biology in cancer research

Tsuyoshi Ikura (Dept. of Mutagenesis, RBC. Kyoto Univ.)

がん研究におけるクロマチン生物学

井倉 毅（京都大・放生研・突然変異・クロマチン制御）

IC1-3

Chromosomal instability and cancer

Kozo Tanaka (Dept. of Mol. Oncol., Inst. Dev. Aging & Cancer, Tohoku Univ.)

染色体不安定性とがん

田中 耕三（東北大・加齢研・分子腫瘍）

IC1-4

Dysregulation of cell signaling pathways in cancer

Mutsuhiro Takekawa (Div. of Cell Signaling & Mol. Med., IMUST)

がんにおけるシグナル伝達の異常

武川 睦寛（東京大・医科研・分子シグナル制御）